03778nam a2200325za 45000010014000000030008000140050017000220070003000390080041000420200037000830200034001200400026001540720016001800720015001960720015002112450068002262600100002943650110003943660035005044900024005395000026005635050821005895201190014105450713026006500034033136500033033476500033033807000020034137000019034339781849841016UK-WkNB20190313000000.0ta190313e201903uuxxk    | |||||||0|0 eng|d  a9781849841016 (pbk.) :cEUR60.00  a1849841012 (pbk.) :cEUR60.00  aUK-WkNBbengcUK-WkNB 7aMJL2bicssc 7aHEA2ukslc 7aMJL2thema14aThe Lung Microbiome /cEdited by Michael J. Cox, Markus J. Ege.  aSheffield :bEuropean Respiratory Society :b[distributor] European Respiratory Society,c2019.  a02b60.00cEURd00eThis price includes a tax elementhZ 60.00 0.00 60.00 0.00jGBkxxkmTEDITOR2onix-pt  b20190312cIPjGBkxxk2UK-WkNB0 aERS Monograph ;v83  aPaperback / softback.0 aSampling-- Techniques: culture, identification and 16S rRNA gene sequencing-- Applying clinical metagenomics for the detection and characteristaion of respiratory infections-- Applying ecological theories in research: lessons learned from microbial ecology and evolution?-- The early-life microbiome: the key to respiratory health?-- From culturomics to metagenomics: the mycobiome in chronic respiratory diseases-- Viruses-- Obstructive airways disease: potential pathogenetic roles-- Chronic suppurative lung disease: cystic fibrosis and non-cystic fibrosis bronchiectasis-- Interstitial lung disease-- The lung bacterial microbiome in community-acquired and nosocomial pneumonia-- Compromised immunity: transplantation, cancer and HIV-- The environmental microbiota and asthma-- Challenges, impact and the future.  aThis Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome, and considers a range of contexts and respiratory diseases.bStudying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including  asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.0 aMichael J. Cox is a microbial ecologist and postdoctoral research associate in the Genomic Medicine section of the National Heart and Lung Institute, Imperial College London (London, UK). He is a co-director of the recently established Microbiome@Imperial network. Markus J. Ege is a professor of clinical respiratory epidemiology at LMU Munich (Munich, Germany). Erika von Mutius is a professor of paediatric allergology. She is head of the Asthma and Allergy Department at the Dr. von Hauner Children's Hospital in Munich (Germany). Since 2017, she has lead the Institute for Asthma and Allergy Prevention at Helmholtz Zentrum Munich - German Research Center for Environmental Health (Neuherberg, Germany). 7aRespiratory medicine.2bicssc 7aHealth and Wellbeing.2ukslc 7aRespiratory medicine.2thema1 aCox, Michael J.1 aEge, Markus J.