AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme
…, N Moore, A Zeaiter, A Das, H Phillips, Z Modrusan… - Advances in …, 2011 - Springer
Despite treatment with the current standard-of-care therapies, patients with newly diagnosed
glioblastoma multiforme (GBM) exhibit dismal prognoses. Bevacizumab has demonstrated …
glioblastoma multiforme (GBM) exhibit dismal prognoses. Bevacizumab has demonstrated …
[PDF][PDF] Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
…, H Colman, L Soroceanu, PM Williams, Z Modrusan… - Cancer cell, 2006 - cell.com
… Values displayed represent Z scores for gene expression of individual samples relative to
the entire sample set. H: In situ hybridization of BCAN and YKL40 in tissue microarray cores of …
the entire sample set. H: In situ hybridization of BCAN and YKL40 in tissue microarray cores of …
Diverse somatic mutation patterns and pathway alterations in human cancers
…, P Waring, SC Schuster, Z Modrusan, Z Zhang… - Nature, 2010 - nature.com
The systematic characterization of somatic mutations in cancer genomes is essential for
understanding the disease and for developing targeted therapeutics 1 . Here we report the …
understanding the disease and for developing targeted therapeutics 1 . Here we report the …
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
…, Y Hu, SM Sa, Q Gong, AR Abbas, Z Modrusan… - Nature medicine, 2008 - nature.com
Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli
O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter …
O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter …
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
…, S Durinck, EW Stawiski, JT Poirier, Z Modrusan… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …
Here, we obtained exome, transcriptome and copy-number alteration data from …
[HTML][HTML] Recurrent R-spondin fusions in colon cancer
S Seshagiri, EW Stawiski, S Durinck, Z Modrusan… - Nature, 2012 - nature.com
Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics 1 . Here we analyse systematically more than 70 pairs of primary …
of targeted therapeutics 1 . Here we analyse systematically more than 70 pairs of primary …
[HTML][HTML] Cross-tissue organization of the fibroblast lineage
…, L Tam, R Caothien, M Roose-Girma, Z Modrusan… - Nature, 2021 - nature.com
… c, Heat map of the relative average expression of the most strongly enriched genes for
each cluster (log(fold change) of one cluster versus all others, z-score by row) with key genes, …
each cluster (log(fold change) of one cluster versus all others, z-score by row) with key genes, …
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
…, TK Cheung, J Fritsche, T Weinschenk, Z Modrusan… - Nature, 2014 - nature.com
… –750 m/z and 800–1,500 m/z for singly … m/z) in the Orbitrap at resolution of 60,000 M/ΔM at
m/z 400, followed by MS/MS (profile) scans in the Orbitrap at resolution of 15,000 M/ΔM at m/z …
m/z 400, followed by MS/MS (profile) scans in the Orbitrap at resolution of 15,000 M/ΔM at m/z …
A comprehensive transcriptional portrait of human cancer cell lines
Tumor-derived cell lines have served as vital models to advance our understanding of
oncogene function and therapeutic responses. Although substantial effort has been made to …
oncogene function and therapeutic responses. Although substantial effort has been made to …
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
…, R Drmanac, Z Modrusan, S Seshagiri, Z Zhang - Nature, 2010 - nature.com
Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell
lung carcinomas in smokers being the predominant form of the disease 1 , 2 . Although …
lung carcinomas in smokers being the predominant form of the disease 1 , 2 . Although …