Efficacy and predictors of rechallenge with immune checkpoint inhibitors in non‐small cell lung cancer

Y Takahara, T Tanaka, Y Ishige, I Shionoya… - Thoracic …, 2022 - Wiley Online Library
Background The efficacy of rechallenge with immune checkpoint inhibitors (ICIs) in non‐small
cell lung cancer (NSCLC) patients has not yet been fully clarified. This study aimed to …

Investigation of response of patients with non‐small cell lung cancer to docetaxel (plus ramucirumab) therapy in second‐line treatment

Y Takahara, R Abe, S Nagae, T Tanaka… - Thoracic …, 2023 - Wiley Online Library
Background Several options for second‐line therapy are available for patients with advanced
non‐small cell lung cancer (NSCLC); however, the optimal therapy remains unclear. …

Serum derivatives of reactive oxygen metabolites are associated with severity of chronic obstructive pulmonary disease and affected by a p53 gene polymorphism

…, R Kato, S Shinomiya, Y Takahara… - … Journal of Chronic …, 2022 - Taylor & Francis
Purpose Oxidative stress is known to activate tumor suppressor p53, which inhibits cell cycle
progression and induces apoptosis. Levels of p53 in lung tissues from patients with chronic …

A case of severe pneumonia caused by Legionella longbeachae with positive results by a Legionella urinary antigen detection kit

…, T Mura, K Nakase, Y Takahara… - Therapeutic …, 2023 - journals.sagepub.com
Legionella longbeachae is a Legionella bacteria often detected in soil, and is known as a rare
cause of Legionella infections in Japan. In addition, detection of this Legionella species is …

Clinical outcomes and survival following placement of self‐expandable metallic stents for central airway stenosis and fistula

…, A Yamagata, Y Iijima, N Motono, Y Takahara… - Thoracic …, 2021 - Wiley Online Library
Background Self‐expandable metallic stent (SEMS) placement is an urgent procedure for
patients with malignant central airway stenoses (CASs) and central airway fistulas (CAFs). The …

Carbonaceous adsorbents produced from coffee lees

…, K Izutsu, M Shioya, T Sakai, Y Takahara… - Journal of materials …, 2009 - Springer
Carbons derived through thermal decomposition of natural products usually showed a texture
reflecting the original structure of the starting material such as the cellular structure. The …

Investigation of response factors for monotherapy with immune checkpoint inhibitors in non‐small cell lung cancer patients with PD‐L1 expression< 50%

Y Takahara, R Abe, N Sumito, T Tanaka… - Thoracic …, 2023 - Wiley Online Library
Background Immune checkpoint inhibitor (ICI) monotherapy is currently approved for the
treatment of advanced non‐small cell lung cancer (NSCLC) patients with programmed death …

Disease control in patients with non‐small cell lung cancer using pemetrexed: Investigating the best treatment strategy

Y Takahara, R Abe, N Sumito, T Tanaka… - Thoracic …, 2024 - Wiley Online Library
… Resources: Yutaka Takahara, Ryudai Abe, Sumito Nagae, Takuya Tanaka, Yoko Ishige, Ikuyo
… : Yutaka Takahara and Taku Oikawa. Writing–original draft preparation: Yutaka Takahara

Risk factors for acute exacerbation in lung cancer complicated by interstitial lung disease with slight reticular shadows

Y Takahara, T Tanaka, Y Ishige, I Shionoya… - Thoracic …, 2021 - Wiley Online Library
Background The risk of cancer treatment‐related acute exacerbation (AE) in patients with
lung cancer and mild interstitial lung disease (ILD) on imaging, classified as indeterminate for …

Synthesis of 2, 7-di-t-butyl-4, 5, 9, 10-tetraphenyltricyclo [6.2. 0.03, 6] deca-1, 3 (6), 4, 7, 9-pentaene. A benzo [1, 2: 4, 5] dicyclobutene.

F Toda, Y Takahara - Bulletin of the Chemical Society of Japan, 1976 - jlc.jst.go.jp
The title compound (15) which has two cyclobutadienes fused to a benzene ring, was
synthesized by heating dl- (7), meso-3,8-di-t-butyl-1,5,6,10-tetraphenyldeca-3,4,6,7-tetraene-1,9-…