Disruption of the klotho Gene Causes Pulmonary Emphysema in Mice: Defect in Maintenance of Pulmonary Integrity during Postnatal Life

…, Y Sando, Y Ohyama, T Maeno, Y Maeno… - American journal of …, 2000 - atsjournals.org
Homozygous mutant klotho (KL −/− ) mice exhibit multiple phenotypes resembling human
aging. In the present study, we focused on examining the pathology of the lungs of klotho mice …

Enantioselective Synthesis of Imidazolines with Quaternary Stereocenters by Organocatalytic Reaction of N-(Heteroarenesulfonyl)imines with Isocyanoacetates

S Nakamura, Y Maeno, M Ohara, A Yamamura… - Organic …, 2012 - ACS Publications
An organocatalytic enantioselective Mannich-type reaction of isocyanoacetate with N-sulfonylimines
catalyzed by chiral thioureas derived from quinine yielded 2-imidazolines with high …

Inducible expression of endothelial PAS domain protein-1 by hypoxia in human lung adenocarcinoma A549 cells: role of Src family kinases-dependent pathway

…, T Maeno, Y Sando, T Suga, Y Maeno… - American journal of …, 2002 - atsjournals.org
Hypoxia is a potent inducer of tumor angiogenesis, the process of which is mostly mediated
by induction of vascular endothelial growth factor (VEGF). In this study, we investigated the …

Stimulation of Vascular Endothelial Growth Factor Gene Transcription by all trans Retinoic Acid through Sp1 and Sp3 Sites in Human Bronchioloalveolar Carcinoma …

T Maeno, T Tanaka, Y Sando, T Suga… - American journal of …, 2002 - atsjournals.org
In this study, we examined the effects of all trans-retinoic acid (at-RA) on the vascular
endothelial growth factor (VEGF) expression in human bronchioloalveolar carcinoma NCI-H322 …

Hange-Shashin-to for preventing diarrhea during afatinib therapy

…, A Kawashima, A Shiono, Y Maeno… - Gan to Kagaku ryoho …, 2015 - europepmc.org
Afatinib is an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). In a
randomized phase III study (Lux-Lung 3 study) employing patients harboring EGFR mutations, …

Pulmonary Intravascular Lymphoma Complicated with Pneumocystis Carinii Pneumonia: a Case Report

…, T Hosono, M Sato, Y Maeno, T Maeno… - Japanese Journal of …, 2001 - academic.oup.com
We report a case of intravascular lymphoma (IVL) complicated with Pneumocystis carinii
pneumonia (PCP). A 65-year-old male complaining of dyspnea and dementia was diagnosed to …

Phase I study evaluating the combination of afatinib with carboplatin and pemetrexed after first-line EGFR-TKIs

…, OU Yamaguchi, AI Masumoto, Y Maeno… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Promising reports have described the combination of first-generation
epidermal growth factor receptor tyrosine-kinase inhibitors (EGFR-TKIs) with carboplatin plus …

Pulmonary nocardiosis during immunosuppressive therapy for idiopathic pulmonary fibrosis

Y Maeno, Y Sando, M Ubukata, T Maeno… - …, 2000 - Wiley Online Library
Nocardiosis is a subacute or chronic suppurative infection caused by Nocardia species.
Although it is more common in immunocompromised hosts, idiopathic pulmonary fibrosis (IPF) …

Indomethacin induced bulky lymphadenopathy and eosinophilic pneumonia

Y Oishi, Y Sando, S Tajima, T Maeno, Y Maeno… - …, 2001 - Wiley Online Library
Indomethacin is one of the most popular non‐steroidal anti‐inflammatory drugs (NSAID).
Although NSAID occasionally provoke bronchospasm and hypersensitivity pneumonia, they …

A case of Sairei-to-induced pneumonitis diagnosed by lymphocyte stimulation test of bronchoalveolar lavage fluid

T Maeno, M Ubukata, Y Maeno, T Suga… - The Japanese journal …, 1997 - jstage.jst.go.jp
症例は 51 歳, 女性. 顔面神経麻痺のため, 柴苓湯の投薬を受けたのち, 乾性咳嗽, 発熱, 労作時
息切れが出現し入院. 入院時 LDH が 481IU/L と上昇し, PaO 2 73.1 Torr と低酸素血症を,% VC 64.1…