Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

…, K Lane, J Harral, M Hoedt-Miller, Y Tada… - Circulation …, 2004 - Am Heart Assoc
Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development,
were recently implicated in the pathogenesis of familial pulmonary arterial hypertension. The …

Diagnostic Usefulness of p16/CDKN2A FISH in Distinguishing Between Sarcomatoid Mesothelioma and Fibrous Pleuritis

…, H Yamakawa, Y Nakatani, Y Tada… - American journal of …, 2013 - academic.oup.com
The distinction between sarcomatoid mesothelioma and fibrous pleuritis is difficult based on
histology, especially when the amount of tumor tissue examined via biopsy is small and …

Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming

…, LJ Robinson, T Blackwell, Y Tada… - Pulmonary …, 2012 - journals.sagepub.com
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease of the lung vasculature
for which the molecular etiologies are unclear. Specific metabolic alterations have been …

Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes

…, B Fouty, S Wu, J West, M Hoedt-Miller, Y Tada… - Circulation …, 2005 - Am Heart Assoc
While Ca 2+ influx is essential for activation of the cell cycle machinery, the processes that
regulate Ca 2+ influx in this context have not been fully elucidated. Electrophysiological and …

[HTML][HTML] Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition

T Suzuki, Y Tada, S Gladson, R Nishimura… - Respiratory …, 2017 - Springer
Background Pulmonary fibrosis is a late manifestation of acute respiratory distress syndrome
(ARDS). Sepsis is a major cause of ARDS, and its pathogenesis includes endotoxin-…

Identification of annexin 1 as a novel autoantigen in acute exacerbation of idiopathic pulmonary fibrosis

…, O Okada, N Yumoto, S Sakao, Y Tada… - The Journal of …, 2008 - journals.aai.org
Consistent with the hypothesis that pulmonary epithelial apoptosis is the key to the acute
exacerbation of idiopathic pulmonary fibrosis (IPF), we conducted serological identification of …

Antiproliferative action of metformin in human lung cancer cell lines

…, A Kitamura, T Chiba, Y Tada… - Oncology …, 2012 - spandidos-publications.com
The oral antidiabetic agent metformin has anticancer properties, probably via adenosine
monophosphate-activated protein kinase activation. In the present study, growth inhibition was …

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

…, X Chen, R Nishimura, Y Tada… - … of Physiology-Lung …, 2018 - journals.physiology.org
Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose
polarity and cell-to cell contacts, and undergo a dramatic remodeling of the cytoskeleton. It …

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

…, S Bai, TR Blackwell, Y Tada… - … of Physiology-Lung …, 2012 - journals.physiology.org
The heritable form of pulmonary arterial hypertension (PAH) is typically caused by a mutation
in bone morphogenic protein receptor type 2 (BMPR2), and mice expressing Bmpr2 …

DNA polymerase κ, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer

J O-Wang, K Kawamura, Y Tada, H Ohmori, H Kimura… - Cancer research, 2001 - AACR
DNA polymerase κ (Pol κ) is a newly identified low-fidelity polymerase implicated in spontaneous
and DNA damage-induced mutagenesis. As an initial study to investigate its possible …