Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study

S Ehara, Y Kobayashi, M Yoshiyama, K Shimada… - Circulation, 2004 - Am Heart Assoc
Background— Calcification is a common finding in human coronary arteries; however, the
relationship between calcification patterns, plaque morphology, and patterns of remodeling of …

Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma

…, Y Konnno, M Chihara, M Itoga, Y Kobayashi… - …, 2013 - Wiley Online Library
Background and objective Epidemiological studies have shown that the prevalence of adult
asthma and severe asthma is higher in women. It has also been reported that female mice …

[HTML][HTML] Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma

N Mercado, A Hakim, Y Kobayashi, S Meah… - PloS one, 2012 - journals.plos.org
Background Severe asthma accounts for a small number of asthmatics but represents a
disproportionate cost to health care systems. The underlying mechanism in severe asthma …

[HTML][HTML] Passive smoking impairs histone deacetylase-2 in children with severe asthma

Y Kobayashi, C Bossley, A Gupta, K Akashi, L Tsartsali… - Chest, 2014 - Elsevier
Background Parental smoking is known to worsen asthma symptoms in children and to make
them refractory to asthma treatment, but the molecular mechanism is unclear. Oxidative …

A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition

Y Kobayashi, H Wada, C Rossios, D Takagi… - … of Pharmacology and …, 2013 - ASPET
Macrolides are reported to reduce exacerbation of chronic inflammatory respiratory disease,
such as chronic obstructive pulmonary disease (COPD), and also show anti-inflammatory …

[HTML][HTML] Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma

Y Kobayashi, N Mercado, PJ Barnes, K Ito - PloS one, 2011 - journals.plos.org
Background Corticosteroid insensitivity is a major barrier of treatment for some chronic
inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity …

The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions

…, Y Yun, D Van Bui, LM Nguyen, Y Kobayashi… - Allergology …, 2021 - jstage.jst.go.jp
Eosinophils not only play a critical role in the pathogenesis of eosinophil-associated diseases,
but they also have multiple important biological functions, including the maintenance of …

Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis

…, Y Ikura, M Ohsawa, H Itabe, Y Kobayashi… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— Recently, elevated levels of plasma oxidized low-density lipoprotein (LDL) have
been shown to relate to plaque instability in human atherosclerotic lesions. We investigated …

p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma

N Mercado, Y To, Y Kobayashi, IM Adcock… - Molecular …, 2011 - ASPET
Corticosteroid insensitivity (CI) is a major barrier to treating severe asthma. Despite intensive
research, the molecular mechanism of CI remains uncertain. The aim of this study was to …

Multiple biological aspects of eosinophils in host defense, eosinophil-associated diseases, immunoregulation, and homeostasis: is their role beneficial, detrimental …

…, K Suzuki, S Sawada, Y Kobayashi… - Biological and …, 2020 - jstage.jst.go.jp
Eosinophils are innate immune leukocytes and play important roles as terminal effector cells
owing to their mediators, such as tissue-destructive cationic proteins, cytokines, chemokines…