Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

…, I Abu-Taha, S Ghezelbash, CL Reynolds, YH Shen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue

…, HS Lu, LA Cassis, JS Coselli, A Daugherty, YH Shen… - Circulation, 2020 - Am Heart Assoc
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life…

14-3-3 proteins; bringing new definitions to scaffolding

G Tzivion, YH Shen, J Zhu - Oncogene, 2001 - nature.com
The 14-3-3 proteins are a part of an emerging family of proteins and protein domains that
bind to serine/threonine-phosphorylated residues in a context specific manner, analogous to …

Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism: a randomized, multicenter …

…, H Dai, K Huang, W Lu, Z Zhang, X Cheng, YH Shen - Chest, 2010 - Elsevier
Background Optimal dosing of the recombinant tissue-type plasminogen activator (rt-PA) is
important in treating pulmonary thromboembolism (PTE). The aim of this study was to …

Free fatty acids inhibit insulin signaling–stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase

…, J Wang, SA LeMaire, JS Coselli, YH Shen - Diabetes, 2006 - Am Diabetes Assoc
In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined
deregulation of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (…

Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance

…, K Pfaller, B Henderson, YH Shen… - … , and vascular biology, 2009 - Am Heart Assoc
Objectives— Although cadmium (Cd) is an important and common environmental pollutant
and has been linked to cardiovascular diseases, little is known about its effects in initial …

Activation of the AMPK-FOXO3 pathway reduces fatty acid–induced increase in intracellular reactive oxygen species by upregulating thioredoxin

…, JS Coselli, L Chen, XL Wang, Y Zhang, YH Shen - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Oxidative stress induced by free fatty acids contributes to the development of
cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may …

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

…, XN Li, L Zhang, XL Wang, L Chen, YH Shen - Biochemical and …, 2010 - Elsevier
Background: Oxidative stress induced by free fatty acids plays a critical role in the pathogenesis
of endothelial dysfunction and atherosclerosis in patients with metabolic syndrome. …

Molecular mechanisms of thoracic aortic dissection

D Wu, YH Shen, L Russell, JS Coselli… - Journal of Surgical …, 2013 - Elsevier
… Author links open overlay panel Darrell Wu MD a b c , Ying H. Shen MD, PhD a b , Ludivine
… Its expression increases within 3 h of the onset of dissection, peaks about 2 wk after onset, …

[HTML][HTML] Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer

…, XH Feng, SM Hartig, F Li, H Shen… - The Journal of …, 2018 - Am Soc Clin Investig
The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated
in many human cancers and plays pivotal roles in tumor progression and therapy resistance. …