Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
…, I Abu-Taha, S Ghezelbash, CL Reynolds, YH Shen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue
…, HS Lu, LA Cassis, JS Coselli, A Daugherty, YH Shen… - Circulation, 2020 - Am Heart Assoc
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life…
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life…
14-3-3 proteins; bringing new definitions to scaffolding
G Tzivion, YH Shen, J Zhu - Oncogene, 2001 - nature.com
The 14-3-3 proteins are a part of an emerging family of proteins and protein domains that
bind to serine/threonine-phosphorylated residues in a context specific manner, analogous to …
bind to serine/threonine-phosphorylated residues in a context specific manner, analogous to …
Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism: a randomized, multicenter …
…, H Dai, K Huang, W Lu, Z Zhang, X Cheng, YH Shen - Chest, 2010 - Elsevier
Background Optimal dosing of the recombinant tissue-type plasminogen activator (rt-PA) is
important in treating pulmonary thromboembolism (PTE). The aim of this study was to …
important in treating pulmonary thromboembolism (PTE). The aim of this study was to …
Free fatty acids inhibit insulin signaling–stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase
…, J Wang, SA LeMaire, JS Coselli, YH Shen - Diabetes, 2006 - Am Diabetes Assoc
In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined
deregulation of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (…
deregulation of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (…
Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance
…, K Pfaller, B Henderson, YH Shen… - … , and vascular biology, 2009 - Am Heart Assoc
Objectives— Although cadmium (Cd) is an important and common environmental pollutant
and has been linked to cardiovascular diseases, little is known about its effects in initial …
and has been linked to cardiovascular diseases, little is known about its effects in initial …
Activation of the AMPK-FOXO3 pathway reduces fatty acid–induced increase in intracellular reactive oxygen species by upregulating thioredoxin
…, JS Coselli, L Chen, XL Wang, Y Zhang, YH Shen - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Oxidative stress induced by free fatty acids contributes to the development of
cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may …
cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may …
Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
…, XN Li, L Zhang, XL Wang, L Chen, YH Shen - Biochemical and …, 2010 - Elsevier
Background: Oxidative stress induced by free fatty acids plays a critical role in the pathogenesis
of endothelial dysfunction and atherosclerosis in patients with metabolic syndrome. …
of endothelial dysfunction and atherosclerosis in patients with metabolic syndrome. …
Molecular mechanisms of thoracic aortic dissection
D Wu, YH Shen, L Russell, JS Coselli… - Journal of Surgical …, 2013 - Elsevier
… Author links open overlay panel Darrell Wu MD a b c , Ying H. Shen MD, PhD a b , Ludivine
… Its expression increases within 3 h of the onset of dissection, peaks about 2 wk after onset, …
… Its expression increases within 3 h of the onset of dissection, peaks about 2 wk after onset, …
[HTML][HTML] Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer
The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated
in many human cancers and plays pivotal roles in tumor progression and therapy resistance. …
in many human cancers and plays pivotal roles in tumor progression and therapy resistance. …