In this article, we review the biology and physiological importance of transforming growth
factor-β (TGF-β) to homeostasis in the respiratory system, its importance to innate and adaptive …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal
disorder. Two US Food and Drug Administration–approved antifibrotic drugs, nintedanib and …

… Drs Aschner, Zemans, and Yamashita have reported that no potential conflicts of interest
exist with any companies/organizations whose products or services may be discussed in this …

Repair of the lung epithelium after injury is integral to the pathogenesis and outcomes of
diverse inflammatory lung diseases. We previously reported that β-catenin signaling promotes …

Background: Genetic susceptibility to diseases is likely influenced by common DNA variants
in the form of single nucleotide polymorphisms (SNPs). The value of SNPs for linkage and …

Receptor-type protein phosphatase α (RPTPα) promotes fibroblast-dependent arthritis and
fibrosis, in part, by enhancing the activation of the kinase SRC. Synovial fibroblasts lining …

Fibrotic lung diseases represent a diverse group of progressive and often fatal disorders
with limited treatment options. Although the pathogenesis of these conditions remains …

Reversible phosphorylation of proteins on tyrosine residues is an essential signaling
mechanism by which diverse cellular processes are closely regulated. The tight temporal and …

Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which
treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-…

The acute respiratory distress syndrome (ARDS) is a major healthcare problem, accounting
for significant mortality and long-term disability. Approximately 25% of patients with ARDS …