Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
X Zheng, JL Carstens, J Kim, M Scheible, J Kaye… - Nature, 2015 - nature.com
Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis
despite current best therapies; therefore new treatment strategies are urgently required. …
despite current best therapies; therefore new treatment strategies are urgently required. …
[PDF][PDF] Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
…, T Pentcheva-Hoang, JL Carstens, X Zheng… - Cancer cell, 2014 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …
Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4–dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways
…, CS De Paiva, X Zhang, G Zhao, X Zheng… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: Allergic diseases affect a large population. Pollen, an ubiquitous allergen,
is the trigger of seasonal rhinitis, conjunctivitis, and asthma, as well as an exacerbating factor …
is the trigger of seasonal rhinitis, conjunctivitis, and asthma, as well as an exacerbating factor …
[HTML][HTML] Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway
X Zheng, CS de Paiva, DQ Li, WJ Farley… - … & visual science, 2010 - arvojournals.org
Purpose.: To explore the phenomenon that corneal and conjunctival tissues subjected to
desiccating stress (DS) promote Th17 differentiation by stimulating the production of Th17-…
desiccating stress (DS) promote Th17 differentiation by stimulating the production of Th17-…
Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer
PDAC is associated with accumulation of dense stroma consisting of fibroblasts and
extracellular matrix that regulate tumor progression. Here, we identify two distinct populations of …
extracellular matrix that regulate tumor progression. Here, we identify two distinct populations of …
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1α (HIF-1α)
becomes stabilized and directly activates transcription of downstream genes. In addition to this …
becomes stabilized and directly activates transcription of downstream genes. In addition to this …
5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops
SR Nallagatla, J Hwang, R Toroney, X Zheng… - science, 2007 - science.org
Molecular patterns in pathogenic RNAs can be recognized by the innate immune system,
and a component of this response is the interferon-induced enzyme RNA-activated protein …
and a component of this response is the interferon-induced enzyme RNA-activated protein …
[HTML][HTML] Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca
CS De Paiva, EA Volpe, NB Gandhi, X Zhang, X Zheng… - PloS one, 2011 - journals.plos.org
Background TGF-β is a pleiotropic cytokine that can have pro- or anti-inflammatory effects
depending on the context. Elevated levels of bioactive TGF-β1 in tears and elevated TGF-…
depending on the context. Elevated levels of bioactive TGF-β1 in tears and elevated TGF-…
[HTML][HTML] WNT4 is required for normal ovarian follicle development and female fertility
A Boyer, É Lapointe, X Zheng, RG Cowan, H Li… - The FASEB …, 2010 - ncbi.nlm.nih.gov
To study the role of WNT4 in the postnatal ovary, a mouse strain bearing a floxed Wnt4
allele was created and mated to the Amhr2 tm3 (cre) Bhr strain to target deletion of Wnt4 to …
allele was created and mated to the Amhr2 tm3 (cre) Bhr strain to target deletion of Wnt4 to …
[PDF][PDF] INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development
The master transcription factors play integral roles in the pluripotency transcription circuitry
of embryonic stem cells (ESCs). How they selectively activate expression of the pluripotency …
of embryonic stem cells (ESCs). How they selectively activate expression of the pluripotency …