[HTML][HTML] Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
…, S Korn, S Ignatenko, W Timmer… - … England Journal of …, 2015 - Mass Medical Soc
Background The most prevalent phenotype of asthma is characterized by eosinophil-dominated
inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of …
inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of …
Decrease in the oral bioavailability of dabigatran etexilate after co‐medication with rifampicin
…, G Nehmiz, U Lemke, W Timmer… - British journal of …, 2012 - Wiley Online Library
… The study was conducted at CRS Clinical Research Services Mannheim GmbH (principal
investigator: Wolfgang Timmer) under the responsibility of the sponsor, Boehringer Ingelheim, …
investigator: Wolfgang Timmer) under the responsibility of the sponsor, Boehringer Ingelheim, …
Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD
KF Rabe, W Timmer, A Sagkriotis, K Viel - Chest, 2008 - Elsevier
Background A 6-week, multicenter, randomized, double-blind, parallel-group study was
conducted in patients with COPD to compare lung function improvements of tiotropium, 18 μg qd…
conducted in patients with COPD to compare lung function improvements of tiotropium, 18 μg qd…
The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise‐Induced Asthma and Leads to Suppression of LPS‐Stimulated TNF‐α Ex Vivo
W Timmer, V Leclerc, G Birraux… - The Journal of …, 2002 - Wiley Online Library
Roflumilast is a new phosphodiesterase 4 (PDE4) inhibitor developed by Byk Gulden
Pharmaceuticals for the treatment of chronic obstructive pulmonary disease and asthma. A placebo…
Pharmaceuticals for the treatment of chronic obstructive pulmonary disease and asthma. A placebo…
Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple …
D Baldoni, M Gutierrez, W Timmer… - Journal of …, 2014 - academic.oup.com
Objectives Current treatment options for Clostridium difficile-associated diarrhoea (CDAD)
leave a high unmet medical need for new therapies. Cadazolid is a new antibiotic in …
leave a high unmet medical need for new therapies. Cadazolid is a new antibiotic in …
[HTML][HTML] Once-daily tiotropium Respimat® 5 μg is an efficacious 24-h bronchodilator in adults with symptomatic asthma
W Timmer, P Moroni-Zentgraf, P Cornelissen… - Respiratory …, 2015 - Elsevier
… Wolfgang Timmer was a clinical investigator and contributed to the study with regard to
patient recruitment and collection of clinical data. Roland Buhl and Emilio Pizzichini were clinical …
patient recruitment and collection of clinical data. Roland Buhl and Emilio Pizzichini were clinical …
The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis
BMW Schmidt, M Kusma, M Feuring, WE Timmer… - Journal of allergy and …, 2001 - Elsevier
Background: The beneficial effects of phosphodiesterase 4 (PDE4) inhibitors in allergic
asthma have been shown in previous preclinical and clinical studies. Because allergic rhinitis …
asthma have been shown in previous preclinical and clinical studies. Because allergic rhinitis …
Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
U Homburg, H Renz, W Timmer, JM Hohlfeld… - Journal of Allergy and …, 2015 - jacionline.org
LETTERS TO THE EDITOR 797 possible, the observed events might also correspond to
mucosal irritation caused by inhalation of the nebulizer formulation. Other respiratory complaints …
mucosal irritation caused by inhalation of the nebulizer formulation. Other respiratory complaints …
[HTML][HTML] Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose …
…, I Heimbeck, C Herpich, N Naue, J Höfler, W Timmer… - BMC Nutrition, 2017 - Springer
Background The development of several disorders, such as cardiovascular diseases, diabetes
and osteoporosis, has been linked to suboptimal dietary magnesium (Mg) intake. In this …
and osteoporosis, has been linked to suboptimal dietary magnesium (Mg) intake. In this …
Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease
P Brand, T Meyer, T Weuthen, W Timmer… - The Journal of …, 2007 - Wiley Online Library
Lung deposition of 18 μg tiotropium administered via a dry‐powder inhaler was investigated
in 5 healthy subjects and patients with mild (n = 4), moderate (n = 6), and severe (n = 5) …
in 5 healthy subjects and patients with mild (n = 4), moderate (n = 6), and severe (n = 5) …