[HTML][HTML] Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme

…, S Korn, S Ignatenko, W Timmer… - … England Journal of …, 2015 - Mass Medical Soc
Background The most prevalent phenotype of asthma is characterized by eosinophil-dominated
inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of …

Decrease in the oral bioavailability of dabigatran etexilate after co‐medication with rifampicin

…, G Nehmiz, U Lemke, W Timmer… - British journal of …, 2012 - Wiley Online Library
… The study was conducted at CRS Clinical Research Services Mannheim GmbH (principal
investigator: Wolfgang Timmer) under the responsibility of the sponsor, Boehringer Ingelheim, …

Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD

KF Rabe, W Timmer, A Sagkriotis, K Viel - Chest, 2008 - Elsevier
Background A 6-week, multicenter, randomized, double-blind, parallel-group study was
conducted in patients with COPD to compare lung function improvements of tiotropium, 18 μg qd…

The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise‐Induced Asthma and Leads to Suppression of LPS‐Stimulated TNF‐α Ex Vivo

W Timmer, V Leclerc, G Birraux… - The Journal of …, 2002 - Wiley Online Library
Roflumilast is a new phosphodiesterase 4 (PDE4) inhibitor developed by Byk Gulden
Pharmaceuticals for the treatment of chronic obstructive pulmonary disease and asthma. A placebo…

Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple …

D Baldoni, M Gutierrez, W Timmer… - Journal of …, 2014 - academic.oup.com
Objectives Current treatment options for Clostridium difficile-associated diarrhoea (CDAD)
leave a high unmet medical need for new therapies. Cadazolid is a new antibiotic in …

[HTML][HTML] Once-daily tiotropium Respimat® 5 μg is an efficacious 24-h bronchodilator in adults with symptomatic asthma

W Timmer, P Moroni-Zentgraf, P Cornelissen… - Respiratory …, 2015 - Elsevier
Wolfgang Timmer was a clinical investigator and contributed to the study with regard to
patient recruitment and collection of clinical data. Roland Buhl and Emilio Pizzichini were clinical …

The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis

BMW Schmidt, M Kusma, M Feuring, WE Timmer… - Journal of allergy and …, 2001 - Elsevier
Background: The beneficial effects of phosphodiesterase 4 (PDE4) inhibitors in allergic
asthma have been shown in previous preclinical and clinical studies. Because allergic rhinitis …

Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma

U Homburg, H Renz, W Timmer, JM Hohlfeld… - Journal of Allergy and …, 2015 - jacionline.org
LETTERS TO THE EDITOR 797 possible, the observed events might also correspond to
mucosal irritation caused by inhalation of the nebulizer formulation. Other respiratory complaints …

[HTML][HTML] Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose …

…, I Heimbeck, C Herpich, N Naue, J Höfler, W Timmer… - BMC Nutrition, 2017 - Springer
Background The development of several disorders, such as cardiovascular diseases, diabetes
and osteoporosis, has been linked to suboptimal dietary magnesium (Mg) intake. In this …

Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease

P Brand, T Meyer, T Weuthen, W Timmer… - The Journal of …, 2007 - Wiley Online Library
Lung deposition of 18 μg tiotropium administered via a dry‐powder inhaler was investigated
in 5 healthy subjects and patients with mild (n = 4), moderate (n = 6), and severe (n = 5) …