Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we used …

Refractoriness to induction chemotherapy and relapse after achievement of remission are
the main obstacles to cure in acute myeloid leukaemia (AML) 1 . After standard induction …

Vascular endothelial growth factor (VEGF), a multifunctional cytokine, potently stimulates
angiogenesis including tumor neovascularization. Although well established in solid tumors, …

Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications
(ITD) occur in 20% of patients with acute myeloid leukemia. They are associated with a …

Introduction: The functions of large noncoding RNAs (ncRNAs) have remained elusive in
many cases. Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an …

… Received more than $2,000 a year from a company for either of the last two years:
Wolfgang E. Berdel, Merck KgaA. … San-Julian M, Diaz-de-Rada P, Noain E, et al: Bone …

The clinical and prognostic relevance of many recently identified driver gene mutations in
adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or …

The importance of angiogenesis for the progressive growth and viability of solid tumors is
well established. In contrast, only few data are available for hematologic neoplasms. To …

PURPOSE: The study was initiated to obtain epidemiologic data and information on anatomic
and histologic distribution, clinical features, and treatment results in patients with primary …

Fifteen patients with refractory AML were treated in a phase 1 study with SU11248, an oral
kinase inhibitor of fms-like tyrosine kinase 3 (Flt3), Kit, vascular endothelial growth factor (…