The function of the right ventricle (RV) determines the prognosis of patients with pulmonary
hypertension. While much progress has been made in the treatment of pulmonary …

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in
zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes …

Background Fibrosis is associated with various cardiac pathologies and dysfunction.
Current quantification methods are time-consuming and laborious. We describe a semi-automated …

In patients with idiopathic pulmonary arterial hypertension (iPAH), iron deficiency is common
and has been associated with reduced exercise capacity and worse survival. Previous …

… Bekedam MA, van Beek-Harmsen BJ, Boonstra A, van Mechelen W, Visser FC, van der
Laarse WJ. Maximum rate of oxygen consumption related to succinate dehydrogenase activity in …

Objectives. SSc-associated pulmonary hypertension (SSc-PH) has a worse prognosis compared
with SSc without PH (SSc-nonPH). Iron deficiency (ID) was previously associated with …

… Willem J. van der Laarse … Wong YY, Handoko ML, Mouchaers KTB, De Man FS, Vonk
Noordegraaf A, Van Der Laarse WJ . Reduced mechanical efficiency of rat papillary muscle related …

Optimizing physical performance is a major goal in current physiology. However, basic
understanding of combining high sprint and endurance performance is currently lacking. This …

Background Near-infrared spectroscopy (NIRS) measurements of oxygenation reflect O 2
delivery and utilization in exercising muscle and may improve detection of a critical exercise …

… Willem J. van der Laarse … Man FS, Happe CM, Schalij I, Musters RJ, Westerhof N, Postmus
PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A. Opposite effects of training in rats …