The innate immune system is crucial for eventual control of infections, but may also contribute
to pathology. Listeria monocytogenes is an intracellular Gram-positive bacteria and a …

The systemic immune response to viral infection is shaped by master transcription factors,
such as NF-κB, STAT1, or PU.1. Although long noncoding RNAs (lncRNAs) have been …

IL-17-producing CD8 + (Tc17) cells are enriched in active lesions of patients with multiple
sclerosis (MS), suggesting a role in the pathogenesis of autoimmunity. Here we show that …

Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic
inflammation. However, the role of lactate in regulating T cell function remains controversial. …

The formation and release of outer membrane vesicles (OMVs) is a phenomenon of Gram-negative
bacteria. This includes Legionella pneumophila (L. pneumophila), a causative agent …

Although it is generally accepted that dietary fiber is health promoting, the underlying
immunological and molecular mechanisms are not well defined, especially with respect to cellulose…

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed
pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent …

Bioactive peptides are key molecules in health and medicine. Deep learning holds a big
promise for the discovery and design of bioactive peptides. Yet, suitable experimental …

The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly
recognized, but the prevalence of autoantibodies in non–SARS-CoV-2 infections and …

Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which
are important mediators of communication and pathogenesis. OMV uptake by host cells …