Acute myeloid leukaemia ( AML ) is a heterogenous disease. Prognosis of AML is influenced
both by patient‐specific as well as disease‐specific factors. Age is the most prominent …

Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we used …

Aberrant DNA methylation patterns are a characteristic feature of cancer including myeloid
malignancies such as acute myeloid leukemia (AML). The mechanisms behind aberrant DNA …

Owing to improvements in our understanding of the biological principles of tumour initiation
and progression, a wide variety of novel targeted therapies have been developed. …

Refractoriness to induction chemotherapy and relapse after achievement of remission are
the main obstacles to cure in acute myeloid leukaemia (AML) 1 . After standard induction …

Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications
(ITD) occur in 20% of patients with acute myeloid leukemia. They are associated with a …

Fifteen patients with refractory AML were treated in a phase 1 study with SU11248, an oral
kinase inhibitor of fms-like tyrosine kinase 3 (Flt3), Kit, vascular endothelial growth factor (…

Vascular endothelial growth factor (VEGF), a multifunctional cytokine, potently stimulates
angiogenesis including tumor neovascularization. Although well established in solid tumors, …

… Berdel, G. Ulrich Exner, Ulrich Göbel, Knut Helmke, Gernot Jundt, Hartmut Kabisch,
Mathias Kevric, Thomas Klingebiel, Rainer Kotz, Rainer Maas, Rudolf Schwarz, Michael …

PURPOSE: The study was initiated to obtain epidemiologic data and information on anatomic
and histologic distribution, clinical features, and treatment results in patients with primary …