Characterization of a common susceptibility locus for asthma-related traits

T Laitinen, A Polvi, P Rydman, J Vendelin, V Pulkkinen… - Science, 2004 - science.org
Susceptibility to asthma depends on variation at an unknown number of genetic loci. To
identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, …

Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics

…, B Nordlund, C Söderhäll, V Pulkkinen… - European …, 2013 - Eur Respiratory Soc
The causes of severe childhood asthma are poorly understood. Our aim was to define global
patterns of gene expression in children with severe therapy-resistant and controlled asthma…

[PDF][PDF] ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis

U Hodgson, V Pulkkinen, M Dixon… - The American Journal of …, 2006 - cell.com
We performed a genomewide scan in six multiplex families with familial idiopathic pulmonary
fibrosis (IPF) who originated from southeastern Finland. The majority of the Finnish …

[HTML][HTML] Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

…, V Fortino, TS Savinko, MT Lehto, V Pulkkinen… - Particle and fibre …, 2014 - Springer
Background Carbon nanotubes (CNT) represent a great promise for technological and
industrial development but serious concerns on their health effects have also emerged. Rod-…

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea

V Pulkkinen, ML Manson, J Säfholm… - … of Physiology-Lung …, 2012 - journals.physiology.org
Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause
bronchodilation. The aim of this study was to extend the information on the effects of bitter taste …

Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease

…, S Bruce, F Bresso, M Zucchelli, S Ezer, V Pulkkinen… - Gastroenterology, 2007 - Elsevier
Background & Aims: The neuropeptide S receptor (NPSR1) gene has been associated
recently with asthma and maps in a region of chromosome 7 previously linked also to …

Characterization of GPRA, a novel G protein–coupled receptor related to asthma

J Vendelin, V Pulkkinen, M Rehn… - American journal of …, 2005 - atsjournals.org
We recently identified a novel positional asthma susceptibility gene, GPRA, which belongs
to the G protein-coupled receptor family. In the present studies, we show that isoform specific …

Characterization of sputum biomarkers for asthma–COPD overlap syndrome

…, T Laitinen, W Mazur, V Pulkkinen - … journal of chronic …, 2016 - Taylor & Francis
Asthma–COPD overlap syndrome (ACOS) is a commonly encountered chronic airway
disease. However, ACOS is still a consensus-based clinical phenotype and the underlying …

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses

V Pulkkinen, S Bruce, J Rintahaka… - The FASEB …, 2010 - Wiley Online Library
Viral infections and abnormal host response are thought to cause epithelial injury in idiopathic
pulmonary fibrosis (IPF). To understand IPF pathogenesis, we have used overexpression …

[HTML][HTML] Soluble receptor for advanced glycation end-products and progression of airway disease

H Iwamoto, J Gao, V Pulkkinen, T Toljamo… - BMC pulmonary …, 2014 - Springer
Background The receptor for advanced glycation end-products (RAGE) is highly expressed
in the lung, where it is believed to have a homeostatic role. Reduced plasma levels of …