Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8) …

MC Li, Q Li, G Yang, VP Kolosov, JM Perelman… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Cold air stimulus is a major environmental factor that exacerbates chronic
inflammatory airway diseases, such as chronic obstructive pulmonary disease (COPD) and …

Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells

H Yu, Q Li, VP Kolosov, JM Perelman… - Cell communication & …, 2010 - Taylor & Francis
Mucus hypersecretion is commonly observed in many chronic airway inflammatory diseases.
Mucin 5AC (MUC5AC) is a major airway mucin because of its high expression in goblet …

Nicotine reduces TNF-α expression through a α7 nAChR/MyD88/NF-ĸB pathway in HBE16 airway epithelial cells

Q Li, XD Zhou, VP Kolosov, JM Perelman - Cellular Physiology and …, 2011 - karger.com
Aims: To explore the signaling mechanism associated with the inhibitory effect of nicotine on
tumor necrosis factor (TNF)- α expression in human airway epithelial cells. Methods: HBE16 …

[HTML][HTML] Impact of atmospheric microparticles on the development of oxidative stress in healthy city/industrial seaport residents

…, T Vitkina, T Gvozdenko, V Kolosov… - … Medicine and Cellular …, 2015 - hindawi.com
Atmospheric microsized particles producing reactive oxygen species can pose a serious
health risk for city residents. We studied the responses of organisms to microparticles in 255 …

Regulation of cigarette smoke‐mediated mucin expression by hypoxia‐inducible factor‐1α via epidermal growth factor receptor‐mediated signaling pathways

H Yu, Q Li, VP Kolosov, JM Perelman… - Journal of applied …, 2012 - Wiley Online Library
Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary
disease (COPD). Mucus hypersecretion is the key manifestation in patients with COPD …

Transient receptor potential melastatin 8 gene polymorphism is associated with cold‐induced airway hyperresponsiveness in bronchial asthma

DE Naumov, JM Perelman, VP Kolosov… - …, 2015 - Wiley Online Library
Background and objective Cold‐induced airway hyperresponsiveness ( CAH ) is common
in bronchial asthma ( BA ) patients and represents a problem for those living in cold climate. …

[HTML][HTML] The degradation of airway epithelial tight junctions in asthma under high airway pressure is probably mediated by Piezo-1

…, G Zhang, L Chen, JM Perelman, VP Kolosov - Frontiers in …, 2021 - frontiersin.org
Full functioning of the airway physical barrier depends on cellular integrity, which is
coordinated by a series of tight junction (TJ) proteins. Due to airway spasm, edema, and mucus …

Cold-inducible RNA-binding protein mediates airway inflammation and mucus hypersecretion through a post-transcriptional regulatory mechanism under cold stress

…, H Huaping, H Zhong, Z Xiangdong, VP Kolosov… - … International Journal of …, 2016 - Elsevier
Acute or chronic cold exposure exacerbates chronic inflammatory airway diseases, such as
chronic obstructive pulmonary disease (COPD) and asthma. Cold-inducible RNA-binding …

MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells

T Zhong, JM Perelman, VP Kolosov, X Zhou - Molecular and cellular …, 2011 - Springer
Mucus hypersecretion is a major manifestation in patients with chronic inflammatory airway
diseases, and MUC5AC protein is a major component of airway mucus. Earlier studies have …

The effect of quercetin on human neutrophil elastase‐induced mucin5AC expression in human airway epithelial cells

N Li, Q Li, XD Zhou, VP Kolosov… - International …, 2012 - Elsevier
Quercetin, a plant flavonoid, is a potent antioxidant and anti-inflammatory agent. Mucus
hypersecretion is a common pathological change in chronic inflammatory diseases of the airway. …