[HTML][HTML] Toxic species in amyloid disorders: Oligomers or mature fibrils
Protein aggregation is the hallmark of several neurodegenerative disorders. These protein
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism of …
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism of …
Neuromuscular junction dysfunction in amyotrophic lateral sclerosis
…, P Chakraborti, M Gourie-Devi, V Taneja - Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive
degeneration of motor neurons leading to skeletal muscle denervation. Earlier studies …
degeneration of motor neurons leading to skeletal muscle denervation. Earlier studies …
Dissecting complex and multifactorial nature of Alzheimer's disease pathogenesis: a clinical, genomic, and systems biology perspective
…, C Rawat, S Kushwaha, R Agarwal, V Taneja… - Molecular …, 2016 - Springer
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
[HTML][HTML] Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Moderate levels of endogenous reactive oxygen species (ROS) are important for various
cellular activities, but high levels lead to toxicity and are associated with various diseases. …
cellular activities, but high levels lead to toxicity and are associated with various diseases. …
[PDF][PDF] A non-Q/N-rich prion domain of a foreign prion,[Het-s], can propagate as a prion in yeast
V Taneja, ML Maddelein, N Talarek, SJ Saupe… - Molecular cell, 2007 - cell.com
Prions are self-propagating, infectious aggregates of misfolded proteins. The mammalian
prion, PrP Sc , causes fatal neurodegenerative disorders. Fungi also have prions. While yeast …
prion, PrP Sc , causes fatal neurodegenerative disorders. Fungi also have prions. While yeast …
[HTML][HTML] An acridine derivative,[4, 5-bis {(N-carboxy methyl imidazolium) methyl} acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor …
aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor …
Use of ade1 and ade2 mutations for development of a versatile red/white colour assay of amyloid‐induced oxidative stress in saccharomyces cerevisiae
Mutations in adenine biosynthesis pathway genes ADE1 and ADE2 have been conventionally
used to score for prion [PSI + ] in yeast. If ade1‐14 mutant allele is present, which contains …
used to score for prion [PSI + ] in yeast. If ade1‐14 mutant allele is present, which contains …
[HTML][HTML] Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex
Small molecules with antioxidative properties have been implicated in amyloid disorders.
Curcumin is the active ingredient present in turmeric and known for several biological and …
Curcumin is the active ingredient present in turmeric and known for several biological and …
Identification of two flavin monooxygenases from an effluent treatment plant sludge metagenomic library
A Singh, NS Chauhan, HV Thulasiram, V Taneja… - Bioresource …, 2010 - Elsevier
Oxygenases are useful for the production of many industrially important molecules. Screening
of an effluent treatment plant (ETP) sludge metagenomic library identified two clones …
of an effluent treatment plant (ETP) sludge metagenomic library identified two clones …
Analyzing the Birth and Propagation of Two Distinct Prions, [PSI+] and [Het-s]y, in Yeast
Various proteins, like the infectious yeast prions and the noninfectious human Huntingtin
protein (with expanded polyQ), depend on a Gln or Asn (QN)-rich region for amyloid formation. …
protein (with expanded polyQ), depend on a Gln or Asn (QN)-rich region for amyloid formation. …