[HTML][HTML] A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
We describe a broad mechanistic framework for the transcriptional induction of mammalian
primary response genes by Toll-like receptors and other stimuli. One major class of primary …
primary response genes by Toll-like receptors and other stimuli. One major class of primary …
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
V Ramirez-Carrozzi, A Sambandam, E Luis, Z Lin… - Nature …, 2011 - nature.com
Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced in epithelia
by bacterial challenge and inflammatory stimuli. Here we show that IL-17C functioned in a …
by bacterial challenge and inflammatory stimuli. Here we show that IL-17C functioned in a …
Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response
VR Ramirez-Carrozzi, AA Nazarian, CC Li… - Genes & …, 2006 - genesdev.cshlp.org
… Mi-2β, the analysis was expanded to include other LPS-induced genes, including genes
described previously and genes identified in microarray experiments (VR Ramirez-Carrozzi and …
described previously and genes identified in microarray experiments (VR Ramirez-Carrozzi and …
The interleukin‐17 cytokine family: critical players in host defence and inflammatory diseases
R Pappu, V Ramirez‐Carrozzi, A Sambandam - Immunology, 2011 - Wiley Online Library
The interleukin‐17 (IL‐17) cytokines, IL‐17A to IL‐17F, are emerging as critical players in
host defence responses and inflammatory diseases. Substantial data support the role of these …
host defence responses and inflammatory diseases. Substantial data support the role of these …
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
…, D Yan, AA Khan, A Abbas, V Ramirez-Carrozzi… - Nature …, 2013 - nature.com
Type 2 innate lymphoid cells (ILC2 cells) participate in host defense against helminth parasites
and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T …
and in allergic inflammation. Given their functional relatedness to type 2 helper T cells (T …
[HTML][HTML] TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers
X Yu, R Pappu, V Ramirez-Carrozzi, N Ota… - Mucosal …, 2014 - nature.com
Immune responses at mucosal barriers are regulated by innate type 2 lymphoid cells (ILC2s)
that elaborate effector cytokines interleukins 5 and 13 (IL5 and IL13). IL25 and IL33 are key …
that elaborate effector cytokines interleukins 5 and 13 (IL5 and IL13). IL25 and IL33 are key …
The IL-17 family cytokines in immunity and disease
R Pappu, V Ramirez-Carrozzi, N Ota… - Journal of clinical …, 2010 - Springer
Introduction Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major
players in the immune response to foreign pathogens. In addition, the pathogeneses of a …
players in the immune response to foreign pathogens. In addition, the pathogeneses of a …
[HTML][HTML] Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ
H Kayama, VR Ramirez-Carrozzi, M Yamamoto… - Journal of biological …, 2008 - ASBMB
Toll-like receptors trigger the induction of primary response genes via MyD88-mediated
activation of NF-κB and other transcription factors. These factors then act in concert with primary …
activation of NF-κB and other transcription factors. These factors then act in concert with primary …
Endogenously expressed IL-13Rα2 attenuates IL-13–mediated responses but does not activate signaling in human lung fibroblasts
…, J Jackman, J Bevers, V Ramirez-Carrozzi… - The Journal of …, 2014 - journals.aai.org
IL-13 can bind to two distinct receptors: a heterodimer of IL-13Rα1/IL-4Rα and IL-13Rα2.
Whereas IL-13Rα1/IL-4Rα engagement by IL-13 leads to the activation of STAT6, the molecular …
Whereas IL-13Rα1/IL-4Rα engagement by IL-13 leads to the activation of STAT6, the molecular …
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma
…, J Wang, J Bevers III, V Ramirez-Carrozzi… - Science translational …, 2022 - science.org
Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial
dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, …
dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, …