Radiotherapy for head and neck cancer is associated with impairment of salivary gland
function and consequent xerostomia, which has a devastating effect on the quality of life of the …

Relatively quiescent tissues like salivary glands (SGs) respond to stimuli such as injury to
expand, replace and regenerate. Resident stem/progenitor cells are key in this process …

Salivary glands are damaged by radiotherapy for head and neck cancers, which often
culminates in radiation-induced hyposalivation and xerostomia that may be permanent. Here, we …

Background The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion
molecule of unknown function expressed in the airway epithelium. Here, we characterize the …

Genetic studies have identified Protocadherin-1 (PCDH1) and Mothers against decapentaplegic
homolog-3 (SMAD3) as susceptibility genes for asthma. PCDH1 is expressed in …

Background Chronic mucus hypersecretion (CMH) is associated with an increased frequency
of respiratory infections, excess lung function decline, and increased hospitalisation and …

Exposure to cigarette smoke (CS) is the main risk factor for developing chronic obstructive
pulmonary disease and can induce airway epithelial cell damage, innate immune responses, …

Over half of patients with brain tumors experience debilitating and often progressive cognitive
decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, …

Protocadherin-1 (PCDH1) is a novel susceptibility gene for airway hyperresponsiveness,
first identified in families exposed to cigarette smoke and is expressed in bronchial epithelial …

Neutrophilic airway inflammation is one of the major hallmarks of chronic obstructive pulmonary
disease and is also seen in steroid resistant asthma. Neutrophilic airway inflammation …