Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

…, RR Vasram, M Lommatzsch, U Harnest… - The lancet respiratory …, 2019 - thelancet.com
Background Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal
antibody that has been shown to safely reduce exacerbations and improve lung function for …

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

D Ukena, U Harnest, R Sakalauskas… - European …, 1997 - Eur Respiratory Soc
The anti-asthmatic effects of theophylline may supplement those of inhaled steroids in
asthma. The aim of the present trial was to study how the addition of theophylline compares to …

Comparison of roflumilast, an oral anti‐inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma

…, LM Adler, P Hofbauer, KD Rost, U Harnest… - Allergy, 2006 - Wiley Online Library
Background: Roflumilast is an oral, once‐daily phosphodiesterase 4 inhibitor with anti‐inflammatory
activity in development for the treatment of asthma. Roflumilast was compared with …

Efficacy and safety of roflumilast in the treatment of asthma

ED Bateman, JL Izquierdo, U Harnest… - Annals of Allergy …, 2006 - Elsevier
… For symptom scores and daily use of rescue medication, the Pratt modification of the Wilcoxon
signed rank test was applied for within-group comparisons, and the Mann-Whitney U test …

Comparison of the efficacy and safety of mometasone furoate dry powder inhaler to budesonide Turbuhaler

…, R Suarez-Chacon, U Harnest… - European …, 2000 - Eur Respiratory Soc
Mometasone furoate (MF) administered by dry powder inhaler (DPI) was composed with
budesonide (BUD) Turbuhaler in the treatment of moderate persistent asthma. The patients …

Onset and duration of action of formoterol and tiotropium in patients with moderate to severe COPD

…, M Mücke, C Sieder, S Schmidtmann, U Harnest… - Respiration, 2006 - karger.com
Background: Chronic obstructive pulmonary disease (COPD) management guidelines
recommend regular treatment with one or more long-acting bronchodilators for patients with …

Comparison of mometasone furoate dry powder inhaler and fluticasone propionate dry powder inhaler in patients with moderate to severe persistent asthma requiring …

U Harnest, D Price, T Howes, G Sussman - Journal of Asthma, 2008 - Taylor & Francis
Background. Inhaled corticosteroids (ICSs) are one of the suggested first-line therapies for
patients with persistent asthma of moderate severity. Methods: The efficacy and safety of …

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

D Ukena, U Harnest, R Sakalauskas… - Pneumologie …, 1998 - europepmc.org
The anti-asthmatic effect of theophylline may supplement those of inhaled steroids in asthma.
The aim of the present trial was to study how the addition of theophylline compares to …

Omalizumab, an anti-IgE antibody, improves both asthma-and rhinitis-related quality of life in patients with concomitant moderate-severe disease

U Harnest, L Boulet, S Hedgecock, M Blogg… - Journal of Allergy and …, 2004 - Elsevier
RATIONALE: Patients with allergic asthma (AA) frequently experience concomitant persistent
allergic rhinitis (PAR). Omalizumab, a humanized monoclonal anti-IgE antibody, improves …

Effectiveness and tolerance of the C3 convertase inhibitor, N-acetyl-aspartyl-magnesium glutamate in perennial rhinitis. Results of a double-blind, placebo-controlled …

U Harnest, R Kiehn, C Sieger, MA Weibel - Arzneimittel-forschung, 1989 - europepmc.org
N-Acetyl-aspartyl magnesium glutamate (Rhinaaxia, NAAGA) is a new antiallergic substance
for topical use. The compound covers a bilateral way of action. There is inhibition of the …