Peripheral tolerance to allergens is mediated in large part by the naturally occurring lung
CD4+ CD25+ T cells, but their effects on allergen-induced airway responsiveness have not …

Objective: Eosinophilic inflammation in the respiratory tract is a hallmark of bronchial asthma.
In naïve cases, the inflammatory profile is associated with disease severity and reactivity to …

Recent studies in both human and rodents have indicated that in addition to CD4+ T cells,
CD8+ T cells play an important role in allergic inflammation. We previously demonstrated that …

BACKGROUND: IL-10 affects dendritic cell (DC) function, but the effects on airway
hyperresponsiveness (AHR) and inflammation are not defined. OBJECTIVE: We sought to determine …

Rationale: Leukotriene B 4 (LTB 4 ) is a rapidly synthesized, early leukocyte chemoattractant
that signals via its cell surface receptor, leukotriene B 4 receptor 1 (BLT1), to attract and …

We report the case of a 44-year-old woman with disseminated Mycobacterium avium complex
(MAC) infection involving multiple bone lesions despite a normal healthy status until 6 …

Background Interferon-γ neutralizing autoantibodies (nIFNγ-autoAbs) are reported in patients
with disseminated nontuberculous mycobacteria (NTM) infection and may function by …

Cytotoxic lymphodepletion therapies augment antitumor immune responses. The generation
and therapeutic efficacy of antitumor effector T cells (T E s) are enhanced during recovery …

We evaluated the role of Syk, using an inhibitor, on allergen-induced airway hyperresponsiveness
(AHR) and airway inflammation in a system shown to be B cell– and mast cell–…

Dendritic cells (DC) are important APCs that control allergen-induced airway responses by
interacting directly with T cells. Leukotriene B 4 (LTB 4), interacting with its high-affinity …