[HTML][HTML] Severe sepsis and septic shock
DC Angus, T Van der Poll - New England journal of medicine, 2013 - Mass Medical Soc
Sepsis, a complex physiological and metabolic response to infection, is a common reason
for admission to an intensive care unit. This review examines the basis, diagnosis, and …
for admission to an intensive care unit. This review examines the basis, diagnosis, and …
The immunopathology of sepsis and potential therapeutic targets
T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …
host response to infection. In sepsis, the immune response that is initiated by an invading …
[HTML][HTML] Redefining critical illness
…, TE Sweeney, BT Thompson, T van der Poll… - Nature medicine, 2022 - nature.com
Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …
Disseminated intravascular coagulation
M Levi, E de Jonge, T van der Poll… - Thrombosis and …, 1999 - thieme-connect.com
A quick literature search in the MEDLINE databases from 1966 to 1998 using the search term
disseminated intravascular coagulation (DIC) and related key words yields an impressive …
disseminated intravascular coagulation (DIC) and related key words yields an impressive …
[HTML][HTML] A guide to immunotherapy for COVID-19
…, APJ Vlaar, M Shankar-Hari, T van der Poll… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …
large body of literature has reported the effect of immune-based therapies in patients with …
Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis
Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes
may allow more precise therapy and improve care. Objective To derive sepsis phenotypes …
may allow more precise therapy and improve care. Objective To derive sepsis phenotypes …
The third international consensus definitions for sepsis and septic shock (Sepsis-3)
…, GS Martin, SM Opal, GD Rubenfeld, T van der Poll… - Jama, 2016 - jamanetwork.com
Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function, …
advances have since been made into the pathobiology (changes in organ function, …
Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
T van der Poll, CV Keogh, X Guirao… - Journal of Infectious …, 1997 - academic.oup.com
… Lowry SF, Calvano SE, van der Poll T. Measurement of … Van der Poll T, Lowry SF. Tumor
necrosis factor in sepsis: … Van der Poll T, van Deventer SJH. The role of tumour necrosis …
necrosis factor in sepsis: … Van der Poll T, van Deventer SJH. The role of tumour necrosis …
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
…, MAD Van Zoelen, W Nacken, D Foell, T Van der Poll… - Nature medicine, 2007 - nature.com
To identify new components that regulate the inflammatory cascade during sepsis, we
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …
IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection
KF van der Sluijs, LJR van Elden, M Nijhuis… - The Journal of …, 2004 - journals.aai.org
Secondary pneumococcal pneumonia is a serious complication during and shortly after
influenza infection. We established a mouse model to study postinfluenza pneumococcal …
influenza infection. We established a mouse model to study postinfluenza pneumococcal …