Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation

…, NSA Patel, R Di Paola, A Ialenti, T Genovese… - European journal of …, 2004 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors that are related to retinoid, …

[HTML][HTML] Focus on the Role of NLRP3 Inflammasome in Diseases

R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation

…, P Dugo, R Di Paola, L Mondello, T Genovese… - Free radical …, 2003 - Taylor & Francis
Anthocyanins are a group of naturally occuring phenolic compounds related to the coloring
of plants, flowers and fruits. These pigments are important as quality indicators, as …

Immunomodulatory effects of etanercept in an experimental model of spinal cord injury

T Genovese, E Mazzon, C Crisafulli, R Di Paola… - … of Pharmacology and …, 2006 - ASPET
Etanercept is a tumor necrosis factor antagonist with anti-inflammatory effects. The aim of our
study was to evaluate for the first time the therapeutic efficacy of in vivo inhibition of tumor …

Effect of rosiglitazone and 15-deoxy-Δ12, 14-prostaglandin J2 on bleomycin-induced lung injury

T Genovese, S Cuzzocrea, R Di Paola… - European …, 2005 - Eur Respiratory Soc
Thiazolidinedione rosiglitazone and 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), are
two peroxisome proliferator-activated receptor (PPAR)-γ ligands. The aim of this study was to …

[HTML][HTML] Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice

A Ahmad, R Crupi, M Campolo, T Genovese… - PloS one, 2013 - journals.plos.org
Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes
to neuronal damage and behavioral impairment. Toll-like receptors (TLRs) are signaling …

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

A Rossi, R Di Paola, E Mazzon, T Genovese… - Journal of pharmacology …, 2009 - ASPET
Myrtucommulone (MC), a nonprenylated acylphloroglucinol contained in the leaves of myrtle
(Myrtus communis), has been reported to suppress the biosynthesis of eicosanoids by …

Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

…, R Di Paola, E Mazzon, T Genovese… - Pharmacological …, 2008 - Elsevier
Glycyrrhizin is a triterpene glycoside, a major active constituent of licorice (Glycyrrhiza
glabra) root and numerous pharmacological effects like anti-inflammatory, anti-viral, anti-tumour …

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

S Ceruti, G Villa, T Genovese, E Mazzon, R Longhi… - Brain, 2009 - academic.oup.com
Upon central nervous system injury, the extracellular concentrations of nucleotides and
cysteinyl-leukotrienes, two unrelated families of endogenous signalling molecules, are markedly …

Uric acid protects against secondary damage after spinal cord injury

GS Scott, S Cuzzocrea, T Genovese… - Proceedings of the …, 2005 - National Acad Sciences
Peroxynitrite contributes to the pathogenesis of various neurodegenerative disorders through
multiple mechanisms and is thought to mediate secondary neuronal cell death after spinal …