[HTML][HTML] The diarylquinoline TMC207 for multidrug-resistant tuberculosis

…, J Allen, JC Palomino, T De Marez… - … England Journal of …, 2009 - Mass Medical Soc
Background The diarylquinoline TMC207 offers a new mechanism of antituberculosis action
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-…

[HTML][HTML] Multidrug-resistant tuberculosis and culture conversion with bedaquiline

…, K Andries, N Bakare, T De Marez… - … England Journal of …, 2014 - Mass Medical Soc
Background Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP
synthase, has been associated with accelerated sputum-culture conversion in patients with …

Bedaquiline in the treatment of multidrug-and extensively drug-resistant tuberculosis

…, K Andries, N Bakare, T De Marez… - European …, 2016 - Eur Respiratory Soc
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (…

[HTML][HTML] A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships

…, NV Voge, B Kesteleyn, P Chaltin, T Jinks, T De Marez… - Antiviral Research, 2023 - Elsevier
While progress has been made in fighting diseases disproportionally affecting underserved
populations, unmet medical needs persist for many neglected tropical diseases. The World …

Pharmacokinetic interaction between darunavir boosted with ritonavir and omeprazole or ranitidine in human immunodeficiency virus-negative healthy volunteers

…, E De Paepe, T De Marez, M De Pauw… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Darunavir (DRV; TMC114; Prezista) is a human immunodeficiency virus (HIV) protease
inhibitor used in combination with low-dose ritonavir (RTV) (DRV/r) as a pharmacokinetic …

Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies

TN Kakuda, B Woodfall, T De Marez… - Journal of …, 2014 - academic.oup.com
Objectives Drug–drug interactions between etravirine and rifabutin or clarithromycin were
examined in two separate open-label, randomized, two-period, crossover trials in HIV-negative…

Pharmacokinetics of darunavir (TMC114) and atazanavir during coadministration in HIV-negative, healthy volunteers

…, T De Marez, S Spinosa-Guzman, M De Pauw… - Drugs in R & D, 2007 - Springer
Background and objective: To investigate the potential for pharmacokinetic interactions
between the protease inhibitors darunavir (DRV, TMC114) coadministered with low-dose …

Induction and suppression of lymphocyte proliferation by antigen extracts of Ostertagia ostertagi

T De Marez, E Cox, E Claerebout, J Vercruysse… - Veterinary immunology …, 1997 - Elsevier
To obtain an insight into the responses of T-cells of cattle to Ostertagia ostertagi, the responses
of peripheral blood and lymph node lymphocytes to O. ostertagi antigen extracts were …

Recombinant bovine interleukin-12 stimulates a gut immune response but does not provide resistance to Cryptosporidium parvum infection in neonatal calves

…, R Fayer, D Zarlenga, A Canals, T De Marez… - Veterinary …, 2006 - Elsevier
This study was undertaken to determine if administration of recombinant bovine interleukin-12
(rBoIL-12) could stimulate a cellular immune response that protected calves from an oral …

Pharmacokinetic interaction between indinavir and darunavir with low-dose ritonavir in healthy volunteers

…, E Lefebvre, T De Marez, M De Pauw, E De Paepe… - Intervirology, 2010 - karger.com
Objective: To investigate the potential for a pharmacokinetic interaction between darunavir (DRV,
TMC114, Prezista®), indinavir (IDV, Crixivan®) and low-dose ritonavir (RTV, Norvir®). …