[HTML][HTML] The diarylquinoline TMC207 for multidrug-resistant tuberculosis
…, J Allen, JC Palomino, T De Marez… - … England Journal of …, 2009 - Mass Medical Soc
Background The diarylquinoline TMC207 offers a new mechanism of antituberculosis action
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-…
by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-…
[HTML][HTML] Multidrug-resistant tuberculosis and culture conversion with bedaquiline
…, K Andries, N Bakare, T De Marez… - … England Journal of …, 2014 - Mass Medical Soc
Background Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP
synthase, has been associated with accelerated sputum-culture conversion in patients with …
synthase, has been associated with accelerated sputum-culture conversion in patients with …
Bedaquiline in the treatment of multidrug-and extensively drug-resistant tuberculosis
…, K Andries, N Bakare, T De Marez… - European …, 2016 - Eur Respiratory Soc
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (…
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (…
[HTML][HTML] A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships
…, NV Voge, B Kesteleyn, P Chaltin, T Jinks, T De Marez… - Antiviral Research, 2023 - Elsevier
While progress has been made in fighting diseases disproportionally affecting underserved
populations, unmet medical needs persist for many neglected tropical diseases. The World …
populations, unmet medical needs persist for many neglected tropical diseases. The World …
Pharmacokinetic interaction between darunavir boosted with ritonavir and omeprazole or ranitidine in human immunodeficiency virus-negative healthy volunteers
…, E De Paepe, T De Marez, M De Pauw… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Darunavir (DRV; TMC114; Prezista) is a human immunodeficiency virus (HIV) protease
inhibitor used in combination with low-dose ritonavir (RTV) (DRV/r) as a pharmacokinetic …
inhibitor used in combination with low-dose ritonavir (RTV) (DRV/r) as a pharmacokinetic …
Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies
TN Kakuda, B Woodfall, T De Marez… - Journal of …, 2014 - academic.oup.com
Objectives Drug–drug interactions between etravirine and rifabutin or clarithromycin were
examined in two separate open-label, randomized, two-period, crossover trials in HIV-negative…
examined in two separate open-label, randomized, two-period, crossover trials in HIV-negative…
Pharmacokinetics of darunavir (TMC114) and atazanavir during coadministration in HIV-negative, healthy volunteers
…, T De Marez, S Spinosa-Guzman, M De Pauw… - Drugs in R & D, 2007 - Springer
Background and objective: To investigate the potential for pharmacokinetic interactions
between the protease inhibitors darunavir (DRV, TMC114) coadministered with low-dose …
between the protease inhibitors darunavir (DRV, TMC114) coadministered with low-dose …
Induction and suppression of lymphocyte proliferation by antigen extracts of Ostertagia ostertagi
T De Marez, E Cox, E Claerebout, J Vercruysse… - Veterinary immunology …, 1997 - Elsevier
To obtain an insight into the responses of T-cells of cattle to Ostertagia ostertagi, the responses
of peripheral blood and lymph node lymphocytes to O. ostertagi antigen extracts were …
of peripheral blood and lymph node lymphocytes to O. ostertagi antigen extracts were …
Recombinant bovine interleukin-12 stimulates a gut immune response but does not provide resistance to Cryptosporidium parvum infection in neonatal calves
…, R Fayer, D Zarlenga, A Canals, T De Marez… - Veterinary …, 2006 - Elsevier
This study was undertaken to determine if administration of recombinant bovine interleukin-12
(rBoIL-12) could stimulate a cellular immune response that protected calves from an oral …
(rBoIL-12) could stimulate a cellular immune response that protected calves from an oral …
Pharmacokinetic interaction between indinavir and darunavir with low-dose ritonavir in healthy volunteers
…, E Lefebvre, T De Marez, M De Pauw, E De Paepe… - Intervirology, 2010 - karger.com
Objective: To investigate the potential for a pharmacokinetic interaction between darunavir (DRV,
TMC114, Prezista®), indinavir (IDV, Crixivan®) and low-dose ritonavir (RTV, Norvir®). …
TMC114, Prezista®), indinavir (IDV, Crixivan®) and low-dose ritonavir (RTV, Norvir®). …