[HTML][HTML] A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure

…, A Gerber, J Trischler, T Zelonina… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Macrophage infiltration is common to both emphysema and atherosclerosis, and cigarette
smoke down-regulates the macrophage cholesterol efflux transporter ATP binding cassette (…

Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice

M Goldklang, P Golovatch, T Zelonina… - … of physiology-lung …, 2012 - journals.physiology.org
Smokers with airflow obstruction have an increased risk of atherosclerosis, but the
relationship between the pathogenesis of these diseases is not well understood. To determine …

[HTML][HTML] Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties

…, SI Zakharov, T Shiomi, T Zelonina… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Large conductance voltage-and calcium-activated potassium (BK) channels are highly
expressed in airway smooth muscle (ASM). Utilizing the ovalbumin (OVA) and house dust mite (…

Attenuation of pulmonary injury by an inhaled MMP inhibitor in the endotoxin lung injury model

…, K Stearns, X Ma, R Xiao, T Zelonina… - … of Physiology-Lung …, 2020 - journals.physiology.org
Acute respiratory distress syndrome (ARDS) is characterized by pulmonary edema and poor
gas exchange resulting from severe inflammatory lung injury. Neutrophilic infiltration and …

The role of secreted frizzled-related protein-1 in allergic asthma

…, E Arteaga-Solis, M Goldklang, T Zelonina… - American Journal of …, 2022 - atsjournals.org
Although allergic asthma is a highly prevalent chronic inflammatory condition, the underlying
pathogenesis driving T-helper cell type 2 inflammation is not well understood. Wnt/β-…

Single-Photon Emission Computed Tomography/Computed Tomography Imaging in a Rabbit Model of Emphysema Reveals Ongoing Apoptosis In Vivo

MP Goldklang, Y Tekabe, T Zelonina… - American Journal of …, 2016 - atsjournals.org
Evaluation of lung disease is limited by the inability to visualize ongoing pathological processes.
Molecular imaging that targets cellular processes related to disease pathogenesis has …

[HTML][HTML] Suppression of cigarette smoke induced MMP1 expression by selective serotonin re‐uptake inhibitors

…, S Jarrod, A Vincent, M Becky, Z Tina - The FASEB …, 2021 - ncbi.nlm.nih.gov
Globally, COPD remains a major cause of disability and death. In the United States alone, it
is estimated that approximately 14 million people suffer from the disease. Given the high …

[HTML][HTML] Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

K Stearns, M Goldklang, R Xiao, T Zelonina… - Plos one, 2021 - journals.plos.org
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease
production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to …

[HTML][HTML] Blocking RAGE expression after injury reduces inflammation in mouse model of acute lung injury

LL Johnson, Y Tekabe, T Zelonina, X Ma, G Zhang… - Respiratory …, 2023 - Springer
Background Receptor for Advanced Glycated Endproducts (RAGE) plays a major role in the
inflammatory response to infectious and toxin induced acute lung injury. We tested the …

[HTML][HTML] Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury

MP Goldklang, Y Tekabe, T Zelonina, J Trischler… - Respiratory …, 2019 - Springer
Background Expression of the Receptor for Advanced Glycation Endproducts (RAGE)
initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE …