User profiles for Tim Sampson
Timothy SampsonAsst. Professor; Emory University Verified email at emory.edu Cited by 8313 |
[HTML][HTML] Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to
neurological disorders. However, a functional link between gut bacteria and …
neurological disorders. However, a functional link between gut bacteria and …
[HTML][HTML] The central nervous system and the gut microbiome
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals.
While historically studied by researching the brain, inputs from the periphery impact many …
While historically studied by researching the brain, inputs from the periphery impact many …
[PDF][PDF] Control of brain development, function, and behavior by the microbiome
TR Sampson, SK Mazmanian - Cell host & microbe, 2015 - cell.com
Animals share an intimate and life-long partnership with a myriad of resident microbial
species, collectively referred to as the microbiota. Symbiotic microbes have been shown to …
species, collectively referred to as the microbiota. Symbiotic microbes have been shown to …
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated)
systems are a bacterial defence against invading foreign nucleic acids derived from …
systems are a bacterial defence against invading foreign nucleic acids derived from …
[HTML][HTML] Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
…, MN Dean, DG Standaert, TR Sampson… - Nature …, 2022 - nature.com
Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
…, X Liu, R Jones, J Haran, B McCormick, TR Sampson… - Gut, 2022 - gut.bmj.com
Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in the
brain and its contribution to Alzheimer’s disease (AD) pathogenesis. Design We analysed …
brain and its contribution to Alzheimer’s disease (AD) pathogenesis. Design We analysed …
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death
of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. …
of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. …
Aptamers and SELEX: the technology
T Sampson - World Patent Information, 2003 - Elsevier
DNA and RNA microarrays have become an important analytical technique in the understanding
and characterisation of genomes and transcriptomes. A recent development in this field …
and characterisation of genomes and transcriptomes. A recent development in this field …
Cas9-mediated targeting of viral RNA in eukaryotic cells
AA Price, TR Sampson, HK Ratner… - Proceedings of the …, 2015 - National Acad Sciences
Clustered, regularly interspaced, short palindromic repeats–CRISPR associated (CRISPR-Cas)
systems are prokaryotic RNA-directed endonuclease machineries that act as an …
systems are prokaryotic RNA-directed endonuclease machineries that act as an …