Rationale Mandibular advancement devices (MADs) are used to treat obstructive sleep
apnoea-hypopnoea syndrome (OSAHS) but evidence is lacking regarding their clinical and cost-…

Objective We sought to identify motor features that would allow the delineation of individuals
with sleep study-confirmed idiopathic REM sleep behavior disorder (iRBD) from controls …

Rationale Methadone is a long-acting μ-opioid and is an effective treatment for heroin addiction.
Opioids depress respiration, and patients receiving methadone maintenance treatment (…

Continuous positive airway pressure (CPAP) remains the gold standard treatment for obstructive
sleep apnoea hypopnoea syndrome (OSAHS). However, the high efficacy of CPAP is …

Obstructive sleep apnoea-hypopnoea (OSAH) causes excessive daytime sleepiness,
impairs quality-of-life, and increases cardiovascular disease and road traffic accident risks. …

Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific
marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline clinical …

Background Invasive ventilation for COPD has significant mortality, and weaning can be
difficult. At Papworth Hospital, we provide a specialist weaning service using noninvasive …

See Postuma (doi: 10.1093/aww131 ) for a scientific commentary on this article. Resting state
functional magnetic resonance imaging dysfunction within the basal ganglia network is a …

Background Compliance with CPAP treatment for OSAS is not reliably predicted by the severity
of symptoms or physiological variables. We examined a range of factors which could be …

Background The evidence base for the treatment of mild obstructive sleep apnoea is limited
and definitions of disease severity vary. The MERGE trial investigated the clinical …