Proteins play an essential role in biology. Whether it is in catalysis or molecular recognition,
proteins set a golden standard of efficiency and selectivity that few other natural or artificial …

Background Hypertension can be controlled adequately with existing drugs such as
angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. Nevertheless, …

Dendritic cells (DCs) are key instigators of adaptive immune responses. Using an alphaviral
expression cloning technology, we have identified the chemokine CCL19 as a potent …

Introducing nonnative metal ions or metal-containing prosthetic groups into a protein can
dramatically expand the repertoire of its functionalities and thus its range of applications. …

Two populations of membrane-bound replication complexes were isolated from poliovirus-infected
HEp-2 cells by sucrose gradient centrifugation. The two fractions show similar …

Background Despite the availability of efficacious drugs, the success of treating hypertension
is limited by patients' inconsistent drug intake. Immunization against angiotensin II may …

The highly conserved non-structural protein 2C of picornaviruses is involved in viral genome
replication and encapsidation and in the rearrangement of intracellular structures. 2C binds …

Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1)
inhibitors and potent anticancer drugs killing cancer cells by producing replication-…

Objective To identify nailfold videocapillaroscopic features and other clinical risk factors for
new digital ulcers (DUs) during a 6‐month period in patients with systemic sclerosis (SSc). …

Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in
tumors has been used as a biomarker for chemotherapeutic efficacy. In this study, we report …