Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

…, E Rietschel, A Heinzmann, B Simma, T Frischer… - Nature, 2007 - nature.com
Asthma is caused by a combination of poorly understood genetic and environmental factors
1 , 2 . We have systematically mapped the effects of single nucleotide polymorphisms (SNPs…

Factors influencing age at diagnosis of primary ciliary dyskinesia in European children

CE Kuehni, T Frischer, MPF Strippoli, E Maurer, A Bush… - 2010 - Eur Respiratory Soc
Primary ciliary dyskinesia (PCD) is a hereditary disorder of mucociliary clearance causing
chronic upper and lower airways disease. We determined the number of patients with …

Mite allergen exposure is a risk for the incidence of specific sensitization

J Kuehr, T Frischer, R Meinert, R Barth, J Forster… - Journal of Allergy and …, 1994 - Elsevier
Background: Mite allergen exposure is essential for the process of specific allergic
sensitization. However, it is not clear whether incidence of specific sensitization at school age …

A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor for Pseudomonas aeruginosa Infection

…, CA Akdis, Z Szépfalusi, T Frischer… - American journal of …, 2013 - atsjournals.org
Rationale: Cystic fibrosis (CF) is characterized by progressive pulmonary inflammation that
is infection-triggered. Pseudomonas aeruginosa represents a risk factor for deterioration of …

Monitoring asthma in children

…, KH Carlsen, E Eber, T Frischer… - European …, 2015 - Eur Respiratory Soc
The goal of asthma treatment is to obtain clinical control and reduce future risks to the
patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all …

Acute effects of particulate matter on respiratory diseases, symptoms and functions:: epidemiological results of the Austrian Project on Health Effects of Particulate …

…, F Horak Jr, H Moshammer, M Kundi, T Frischer… - Atmospheric …, 2004 - Elsevier
To examine hypotheses regarding health effects of particulate matter, we conducted time
series studies in Austrian urban and rural areas. Of the pollutants measured, ambient PM 2.5 …

Management of primary ciliary dyskinesia in European children: recommendations and clinical practice

MPF Strippoli, T Frischer, A Barbato… - European respiratory …, 2012 - Eur Respiratory Soc
The European Respiratory Society Task Force on primary ciliary dyskinesia (PCD) in
children recently published recommendations for diagnosis and management. This paper …

Exhaled nitric oxide in the management of childhood asthma: a prospective 6‐months study

…, E Dehlink, Z Szepfalusi, T Frischer - Pediatric …, 2006 - Wiley Online Library
Fractional exhaled nitric oxide (FeNO) is elevated in asthma and reflects eosinophilic airway
inflammation. The aim of this prospective, randomized, single‐blind study was to examine …

The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies

…, W Seeger, FJ Kelly, C Dunster, T Frischer… - American journal of …, 2000 - atsjournals.org
The aim of this study was to investigate the cellular and biochemical events associated with
repeated exposures to ozone. Twenty-three healthy subjects underwent single exposures to …

Lung function growth and ambient ozone: a three-year population study in school children

T Frischer, M Studnicka, C Gartner… - American journal of …, 1999 - atsjournals.org
We followed a cohort of 1,150 children for 3 yr to investigate long-term effects of ambient
ozone. Nine study sites were selected on the basis of air-quality data to represent a broad …