Human BDCA3 + dendritic cells (DCs) were suggested to be homologous to mouse CD8α +
DCs. We demonstrate that human BDCA3 + DCs are more efficient than their BDCA1 + …

Disclosures: S. Ehrmann reported personal fees from Aerogen, grants from Fisher & Paykel,
grants from Hamilton Medical, and personal fees from La Diffusion Technique Française …

Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity
and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved …

In previous studies, fosmidomycin has been shown to possess activity against Plasmodium
falciparum in vitro and in the mouse model. It has a novel mode of action through inhibition of …

Safe and effective antimalarial drugs with new methods of action are urgently needed.
Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the …

During evolution, vertebrates have developed an adaptive immune system able to cope
with a variety of pathogens. Dendritic cells (DCs) are central to this process. DCs integrate …

Tumors poorly infiltrated by T cells are more resistant to immunogenic chemotherapies and
checkpoint inhibition than highly infiltrated tumors. Using murine models, we found that …

In numerous airway diseases, such as cystic fibrosis, the epithelium is severely damaged
and must regenerate to restore its defense functions. Although the human airway epithelial …

DC s express receptors sensing microbial, danger or cytokine signals, which when triggered
in combination drive DC maturation and functional polarization. Maturation was proposed to …

Type I interferons (IFNs) are central to antiviral defense, but how they orchestrate immune
cell function is incompletely understood. We determined that IFNs produced during murine …