Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation
MG Duvall, TR Bruggemann, BD Levy - Molecular aspects of medicine, 2017 - Elsevier
Bronchi are exposed daily to irritants, microbes and allergens as well as extremes of temperature
and acid. The airway mucosal epithelium plays a pivotal role as a sentinel, releasing …
and acid. The airway mucosal epithelium plays a pivotal role as a sentinel, releasing …
Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma
N Krishnamoorthy, DN Douda, TR Brüggemann… - Science …, 2018 - science.org
… Pearson correlation r values and significance are noted for each correlation, and regression
… Correlations were evaluated by Pearson’s correlation coefficient (r). For table S2, …
… Correlations were evaluated by Pearson’s correlation coefficient (r). For table S2, …
The Maresin 1–LGR6 axis decreases respiratory syncytial virus-induced lung inflammation
N Krishnamoorthy, KH Walker… - Proceedings of the …, 2023 - National Acad Sciences
The resolution of infection is an active process with specific molecular and cellular mechanisms
that temper inflammation and enhance pathogen clearance. Here, the specialized pro-…
that temper inflammation and enhance pathogen clearance. Here, the specialized pro-…
[HTML][HTML] Protectins PCTR1 and PD1 reduce viral load and lung inflammation during respiratory syncytial virus infection in mice
KH Walker, N Krishnamoorthy… - Frontiers in …, 2021 - frontiersin.org
Viral pneumonias are a major cause of morbidity and mortality, owing in part to dysregulated
excessive lung inflammation, and therapies to modulate host responses to viral lung injury …
excessive lung inflammation, and therapies to modulate host responses to viral lung injury …
Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes
BD Levy, REE Abdulnour, A Tavares… - Journal of Allergy and …, 2020 - Elsevier
Background Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic
patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, …
patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, …
Cromolyn Sodium differentially regulates human mast cell and mouse leukocyte responses to control allergic inflammation
PG Puzzovio, TR Brüggemann, H Pahima… - Pharmacological …, 2022 - Elsevier
Background Cromolyn Sodium (CS) has been used in the past as an anti-allergy drug
owing to its mast cell (MC) stabilizing properties that impair histamine release. However, …
owing to its mast cell (MC) stabilizing properties that impair histamine release. However, …
Cysteinyl maresins reprogram macrophages to protect mice from streptococcus pneumoniae after Influenza A virus infection
L P. Tavares, TR Brüggemann, R M. Rezende… - MBio, 2022 - Am Soc Microbiol
Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality
during IAV epidemics and pandemics is attributable to secondary bacterial infections, …
during IAV epidemics and pandemics is attributable to secondary bacterial infections, …
Eosinophil phenotypes are functionally regulated by resolvin D2 during allergic lung inflammation
TR Brüggemann, HY Peh, LP Tavares… - American journal of …, 2023 - atsjournals.org
… The difference in the R i became even more evident when calculated as the time to reach
70… an R i to reach T 70 of 1.6 days in comparison with Veh that had a significantly longer R i to …
70… an R i to reach T 70 of 1.6 days in comparison with Veh that had a significantly longer R i to …
[HTML][HTML] Effects of high-intensity swimming on lung inflammation and oxidative stress in a murine model of DEP-induced injury
LCM Ávila, TR Bruggemann, F Bobinski, MD da Silva… - PloS one, 2015 - journals.plos.org
Studies have reported that exposure to diesel exhaust particles (DEPs) induces lung
inflammation and increases oxidative stress, and both effects are susceptible to changes via …
inflammation and increases oxidative stress, and both effects are susceptible to changes via …
Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation
…, TR Brüggemann, MG Duvall, R Nshimiyimana… - …, 2024 - pubmed.ncbi.nlm.nih.gov
… 1 , Thayse R Brüggemann …