A European Respiratory Society technical standard: exhaled biomarkers in lung disease

…, A Spanevello, T Tonia, TJ Vink - European …, 2017 - Eur Respiratory Soc
Breath tests cover the fraction of nitric oxide in expired gas (F ENO ), volatile organic compounds
(VOCs), variables in exhaled breath condensate (EBC) and other measurements. For …

An electronic nose in the discrimination of patients with asthma and controls

…, A Spanevello, O Resta, NP Willard, TJ Vink… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Exhaled breath contains thousands of volatile organic compounds (VOCs)
that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC …

Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD

…, S Peters, T Dekker, HH Knobel, TJ Vink… - European …, 2011 - Eur Respiratory Soc
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) is predictive for
responses to inhaled steroids. We hypothesised that the inflammatory subtype in mild and …

Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome

…, HH Knobel, TME Nijsen, TJ Vink… - European …, 2014 - Eur Respiratory Soc
There is a need for biological markers of the acute respiratory distress syndrome (ARDS).
Exhaled breath contains hundreds of metabolites in the gas phase, some of which reflect (…

Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma

…, MM Sneeboer, HH Knobel, TJ Vink… - Clinical & …, 2017 - Wiley Online Library
Background Asthma is a chronic inflammatory airway disease, associated with episodes of
exacerbations. Therapy with inhaled corticosteroids ( ICS ) targets airway inflammation, …

Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

…, Y Wang, H Weda, HH Knobel, TJ Vink… - Journal of Allergy and …, 2019 - Elsevier
Background Severe asthma is a heterogeneous condition, as shown by independent cluster
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …

Exhaled volatile organic compounds as markers for medication use in asthma

…, C Gómez, HH Knobel, H Weda, TJ Vink… - European …, 2020 - Eur Respiratory Soc
Introduction Asthma is a heterogeneous condition, characterised by chronic inflammation of
the airways, typically managed with inhaled bronchodilators and corticosteroids. In the case …

A simple breath sampling method in intubated and mechanically ventilated critically ill patients

…, APGE Janssen, HH Knobel, TJ Vink… - Respiratory physiology …, 2014 - Elsevier
Volatile organic compounds (VOCs) in breath may serve as biomarkers of pulmonary infection
or inflammation. We developed and validated a new breath sampling method for VOC …

Methodological considerations for large-scale breath analysis studies: lessons from the U-BIOPRED severe asthma project

…, R Goodacre, N Rattray, TJ Vink… - Journal of breath …, 2018 - iopscience.iop.org
Methods for breath sampling and analysis require robust quality assessment to minimise the
risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies …

Levels of cytokines in broncho-alveolar lavage fluid, but not in plasma, are associated with levels of markers of lipid peroxidation in breath of ventilated ICU patients

…, HH Knobel, H Weda, TME Nijsen, TJ Vink… - Journal of breath …, 2015 - iopscience.iop.org
Alkanes and alkenes in the breath are produced through fatty acid peroxidation, which is
initialized by reactive oxygen species. Inflammation is an important cause and effect of reactive …