HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer

…, N Rama, C Datler, JB Studd, R Agarwal, TG Guney… - Cancer research, 2011 - AACR
Ovarian cancer frequently acquires resistance to platinum chemotherapy, representing a major
challenge for improving patient survival. Recent work suggests that resistant clones exist …

[PDF][PDF] Epithelial–stromal cell interactions and extracellular matrix mechanics drive the formation of airway-mimetic tubular morphology in lung organoids

TG Güney, AM Herranz, S Mumby, IE Dunlop… - Iscience, 2021 - cell.com
Complex human airway cellular organization where extracellular matrix (ECM) and epithelial
and stromal lineages interact present challenges for organ study in vitro. Current in vitro …

Structure-function relationships of mucociliary clearance in human airways

…, EJ Quiroz, BA Calvert, A van der Does, TG Güney… - bioRxiv, 2023 - biorxiv.org
Mucociliary clearance (MCC) is a key mechanical defense mechanism of the human airways,
and MCC failure is linked to major respiratory diseases. While single-cell transcriptomics …

Increased expression of sphingosine-1-phosphate and S1PR2 are associated with attenuated macrophage phagocytosis in COPD

TG Guney, R Holloway, A Taylor, C Thomas, P Barnes… - 2013 - Eur Respiratory Soc
Sphingosine-1-phosphate (S1P) is a lipid mediator that may alter macrophage polarisation
and function. S1P is synthesised by SPHK1 and SPHK2 and acts via S1P receptors. Its role …

Epithelial-stromal cell interactions and ECM mechanics drive the formation of airway-mimetic tubular morphology in lung organoids

TG Guney, AM Herranz, S Mumby, IE Dunlop… - bioRxiv, 2020 - biorxiv.org
The complex cellular organisation of the human airway tract where interaction between
epithelial and stromal lineages and the extracellular matrix (ECM) make it a difficult organ to …

Development Of A Novel 3 Dimensional Organoid Culture Of The Airway Lumen

TG Guney, H Danahay, F Chung, S Mumby… - … AND THE MATRIX, 2016 - atsjournals.org
Rationale: surrounded by extracellular matrix proteins and contains goblet cells that secrete
mucus into the airway lumen. Current models of the airway such as monolayer and air liquid …

Characterisation of a novel 3D model of the airways

TG Guney, H Danahay, AL Durham, C Rossios… - 2015 - Eur Respiratory Soc
Asthma and COPD are major causes of mortality and morbidity worldwide. Whilst the aetiology
underlying both diseases are different, chronic inflammation and structural changes to the …

D29 UNRAVELING THE EXTRACELLULAR MATRIX: 3-D Organoid Model Of COPD Senescence

TG Guney, S Mumby, KF Chung… - American Journal of …, 2017 - search.proquest.com
Bronchospheres are formed from self-organisation of basal epithelial cells in ECM into semi-spheres
that form an accessible inner vacuole with a functional pseudostratified lumen. The …

Facile surface modification method for synergistically enhancing the biocompatibility and bioactivity of poly (ether ether ketone) that induced osteodifferentiation

Y Zhu, Z Cao, Y Peng, L Hu, T Guney… - ACS applied materials & …, 2019 - ACS Publications
Poly(ether ether ketone) (PEEK) is a promising material in biomedical engineering due to its
suitable mechanical properties and excellent chemical resistance and biocompatibility. …

[HTML][HTML] The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma

EA Stronach, P Cunnea, C Turner, T Guney… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Platinum based drugs are the cornerstone of chemotherapy for ovarian cancer, however the
development of chemoresistance hinders its success. IL-8 is involved in regulating several …