Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non‐neoplastic diseases

T Shiomi, V Lemaître, J D'Armiento… - Pathology …, 2010 - Wiley Online Library
Takayuki Shiomi and Vincent Lemaître contributed equally to … Takayuki Shiomi and Vincent
Lemaître contributed equally to … Takayuki Shiomi and Vincent Lemaître contributed equally to …

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

I Inoki, T Shiomi, G Hashimoto, H Enomoto… - The FASEB …, 2002 - Wiley Online Library
Vascular endothelial growth factor (VEGF) is a strong angiogenic mitogen and plays
important roles in angiogenesis under various pathophysiological conditions. The in vivo …

[PDF][PDF] Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging

…, S Reiken, AC Meli, A Umanskaya, W Xie, T Shiomi… - Cell metabolism, 2011 - cell.com
Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased
mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum …

MT1-MMP and MMP-7 in invasion and metastasis of human cancers

T Shiomi, Y Okada - Cancer and metastasis reviews, 2003 - Springer
Previous experimental and biochemical studies on matrix metalloproteinases (MMPs) have
indicated that MMPs are implicated in cancer invasion and metastases. Studies on the …

[HTML][HTML] MMP-1 drives immunopathology in human tuberculosis and transgenic mice

P Elkington, T Shiomi, R Breen… - The Journal of …, 2011 - Am Soc Clin Investig
Most individuals infected with Mycobacterium tuberculosis develop a latent infection, which
does not progress to active tuberculosis (TB). This occurs, in part, because infected …

Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage

H Enomoto, I Inoki, K Komiya, T Shiomi, E Ikeda… - The American journal of …, 2003 - Elsevier
To assess the possible involvement of vascular endothelial growth factor (VEGF) in the
pathology of osteoarthritic (OA) cartilage, we examined the expression of VEGF isoforms and …

Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis

…, S Yuasa, K Matsumura, K Kimura, T Shiomi… - Nature medicine, 2006 - nature.com
The avascularity of cardiac valves is abrogated in several valvular heart diseases (VHDs).
This study investigated the molecular mechanisms underlying valvular avascularity and its …

ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal …

…, A Okada, T Ohtsuka, M Shimoda, T Shiomi… - The American journal of …, 2004 - Elsevier
ADAMs (a disintegrin and metalloproteinases) are multifunctional molecules involved in cell-cell
fusion, cell adhesion, membrane protein shedding, and proteolysis. In the present study…

Expression of ADAMTS4 (aggrecanase‐1) in human osteoarthritic cartilage

S Naito, T Shiomi, A Okada, T Kimura… - Pathology …, 2007 - Wiley Online Library
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)1, 4, 5, 8, 9 and
15, members of the ADAMTS gene family, have the ability to degrade a major cartilage …

The extracellular matrix regulates granuloma necrosis in tuberculosis

B Al Shammari, T Shiomi, L Tezera… - The Journal of …, 2015 - academic.oup.com
A central tenet of tuberculosis pathogenesis is that caseous necrosis leads to extracellular
matrix destruction and bacterial transmission. We reconsider the underlying mechanism of …