[HTML][HTML] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

…, S Ito, H Utsumi, H Wakui, T Numata… - Nature …, 2019 - nature.com
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis …

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

S Minagawa, J Araya, T Numata… - … of Physiology-Lung …, 2011 - journals.physiology.org
Reepithelialization of remodeled air spaces with bronchial epithelial cells is a prominent
pathological finding in idiopathic pulmonary fibrosis (IPF) and is implicated in IPF pathogenesis. …

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

…, H Wakui, S Fujii, J Kojima, K Shimizu, T Numata… - Autophagy, 2015 - Taylor & Francis
Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species
(ROS) production has been implicated in COPD pathogenesis by accelerating senescence…

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

…, S Minagawa, Y Yumino, T Ishikawa, T Numata… - …, 2012 - Taylor & Francis
Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by …

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

…, J Kojima, K Shimizu, T Numata… - … of Physiology-Lung …, 2013 - journals.physiology.org
Mitochondria are dynamic organelles that continuously change their shape through fission
and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through …

[HTML][HTML] Metformin attenuates lung fibrosis development via NOX4 suppression

…, H Utsumi, H Wakui, J Kojima, T Numata… - Respiratory …, 2016 - Springer
Background Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial
process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, …

Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence

…, C Tsurushige, J Kojima, T Numata… - The Journal of …, 2014 - journals.aai.org
Cigarette smoke (CS)–induced cellular senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

…, M Hashimoto, H Wakui, T Ishikawa, T Numata… - Autophagy, 2019 - Taylor & Francis
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a …

Involvement of PARK2-mediated mitophagy in idiopathic pulmonary fibrosis pathogenesis

…, H Wakui, J Kojima, K Shimizu, T Numata… - The Journal of …, 2016 - journals.aai.org
Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic pulmonary
fibrosis (IPF), are composed of fibrogenic myofibroblasts. Autophagy has been implicated …

Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4

…, H Wakui, Y Yoshii, T Ishikawa, T Numata… - Autophagy, 2017 - Taylor & Francis
Accumulation of profibrotic myofibroblasts is involved in the process of fibrosis development
during idiopathic pulmonary fibrosis (IPF) pathogenesis. TGFB (transforming growth factor β) …