The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

AG Fraser, TR Orchard, DP Jewell - Gut, 2002 - gut.bmj.com
Background: There are limited data on factors predicting response to azathioprine and
uncertainty regarding the optimal duration of treatment. Patients and methods: The notes of …

A comparison of segmental vs subtotal/total colectomy for colonic Crohn's disease: a meta‐analysis

…, T Athanasiou, AG Heriot, TR Orchard… - Colorectal …, 2006 - Wiley Online Library
Objective Using meta‐analytical techniques the present study evaluated differences in short‐term
and long‐term outcomes of adult patients with colonic Crohn's disease who underwent …

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

…, H Poustchi, WG Newman, V Midha, TR Orchard… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Extraintestinal manifestations of inflammatory bowel disease

H Williams, D Walker, TR Orchard - Current gastroenterology reports, 2008 - Springer
The idiopathic inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis,
may be complicated by extraintestinal manifestations (EIMs) in up to 40% of patients. Reports …

Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history

TR Orchard, BP Wordsworth, DP Jewell - Gut, 1998 - gut.bmj.com
Background—Peripheral arthropathy is a well-recognised complication of inflammatory
bowel disease (IBD). Little is known of its natural history, but a variety of joint involvement has …

The molecular classification of the clinical manifestations of Crohn's disease

…, K Mulcahy–Hawes, SE Marshall, TR Orchard… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS:: Crohn's disease is a common inflammatory disorder of the gut
characterized by variation in both location and behavior. Chromosome 16 and the HLA region …

Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes

TR Orchard, CN Chua, T Ahmad, H Cheng, KI Welsh… - Gastroenterology, 2002 - Elsevier
Background & Aims: There are few systematic studies on the natural history or immunogenetic
associations of erythema nodosum (EN) or ocular inflammation in inflammatory bowel …

Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease

…, C Simillis, AW Darzi, TR Orchard… - Official journal of the …, 2006 - journals.lww.com
AIMS The aim of this study was to assess the diagnostic precision of anti Saccharomyces
cerevisiae (ASCA) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) in …

Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease

TR Orchard, S Thiyagaraja, KI Welsh, BP Wordsworth… - Gastroenterology, 2000 - Elsevier
Background & Aims: The detection of phenotype-determining genes as opposed to disease
susceptibility genes requires precise phenotypic characterization of patients. Peripheral …

Characterization of inflammatory bowel disease with urinary metabolic profiling

…, SD Taylor-Robinson, TR Orchard - Official journal of the …, 2009 - journals.lww.com
Orchard. Most patients were under the care of Huw JW Thomas, Julian P. Teare, and …
Orchard who all participated in active recruitment. Sample collection: Horace RT Williams, Simon …