As the prototype of a family of transcription factors, Sp1 has been extensively studied and
widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was …

Objective To describe our experience with 6 patients and to review the current literature to
update the approach to the diagnosis and treatment of chronic necrotizing pulmonary …

We examined the effects of activation of endothelial protein kinase C (PKC) of the
endothelial barrier function. Exposure of confluent bovine pulmonary artery endothelial cell …

We studied the relationship between body mass index (BMI) on responses to asthma
therapy using a retrospective analysis of four previously reported clinical trials. Fluticasone …

We tested the hypothesis that human recombinant tumor necrosis factor-alpha (TNF) promotes
pulmonary edema by neutrophil-dependent effects on the pulmonary vasculature. The …

We tested the hypothesis that tumor necrosis factor-alpha (TNF) induces a peroxynitrite (ONOO-)-mediated
depletion of glutathione via a protein kinase C (PKC)-dependent mechanism …

We studied the effects of intravenous infusion of recombinant human tumor necrosis factor
type alpha (rTNF-alpha; 12 micrograms/kg) on lung fluid balance in sheep prepared with …

Background Increased rates of respiratory adverse events have been observed in people ≥12
years of age with cystic fibrosis homozygous for the Phe508del-CFTR mutation treated …

… Ferro TJ: Former employee of Sanofi at the time of the study conduct and may hold stock
and/or stock options in the company. Ferro TJ is currently employee of Sun Pharma, Princeton, …

We tested the hypothesis that nitric oxide (.NO) mediates tumor necrosis factor-alpha (TNF-alpha)-induced
alterations in permeability and actin of pulmonary artery endothelial …