Generation of C5a in the absence of C3: a new complement activation pathway

…, JV Sarma, FS Zetoune, D Rittirsch, TA Neff… - Nature medicine, 2006 - nature.com
Complement-mediated tissue injury in humans occurs upon deposition of immune complexes,
such as in autoimmune diseases and acute respiratory distress syndrome. Acute lung …

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

NC Riedemann, TA Neff, RF Guo… - The Journal of …, 2003 - journals.aai.org
IL-6 is known to be an important pro-and anti-inflammatory cytokine, which is up-regulated
during sepsis. Our previous work has suggested a role for IL-6 in the up-regulation of C5aR in …

[HTML][HTML] Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international …

…, N Gehring, A Heise, T Huebner, TA Neff… - …, 2020 - thelancet.com
Background Coronavirus disease 2019 (COVID-19) is associated with a high disease
burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the …

Anesthetic-induced improvement of the inflammatory response to one-lung ventilation

…, RC Schimmer, R Klaghofer, TA Neff… - The Journal of the …, 2009 - pubs.asahq.org
Background Although one-lung ventilation (OLV) has become an established procedure
during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, …

[HTML][HTML] Increased C5a receptor expression in sepsis

NC Riedemann, RF Guo, TA Neff… - The Journal of …, 2002 - Am Soc Clin Investig
Excessive production of the complement activation product C5a appears to be harmful during
the development of sepsis in rodents. Little is known about the role of the C5a receptor (…

[PDF][PDF] Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML

FH Heidel, L Bullinger, Z Feng, Z Wang, TA Neff… - Cell stem cell, 2012 - cell.com
A key characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Genetic
deletion of β-catenin during fetal HSC development leads to impairment of self-renewal while …

Pharmacokinetics of hydroxyethyl starch

C Jungheinrich, TA Neff - Clinical pharmacokinetics, 2005 - Springer
Hydroxyethyl starch has recently become the subject of renewed interest because of the
introduction of a new specification, hydroxyethyl starch 130/0.4, as well as the clinical …

Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury

TA Neff, M Doelberg, C Jungheinrich… - Anesthesia & …, 2003 - journals.lww.com
In this prospective, controlled, randomized, single-center study, we investigated the safety of
repetitive large-dose infusion of a novel hydroxyethyl starch solution (6% HES 130/0.4) in …

Miliary tuberculosis

SA Sahn, TA Neff - The American journal of medicine, 1974 - Elsevier
Neff TA. Coan BJ: Incidence of drug intolerance to antituberculosis chemotherapy, Dis
Chest 56: 10, 1969. Place VA, Pyle MM, DeLaHuerga J: Ethambutol in tuberculous meningitis. …

Regulatory role of C5a in LPS‐induced IL‐6 production by neutrophils during sepsis

…, RF Guo, TJ Hollmann, H Gao, TA Neff… - The FASEB …, 2004 - Wiley Online Library
Experimental sepsis in rodents occurring after cecal ligation/puncture (CLP) is associated
with excessive complement activation and a systemic inflammatory response. The …