To establish diagnostic performance of the cerebrospinal fluid (CSF) biomarkers β-amyloid
peptide (Aβ 1–42 ), total tau-protein (T-tau) and tau phosphorylated at threonine 181 (P-tau …

Studies of inbreeding depression or kin selection require knowledge of relatedness between
individuals. If pedigree information is lacking, one has to rely on genotypic information to …

Context-dependent biological variation presents a unique challenge to the reproducibility of
results in experimental animal research, because organisms’ responses to experimental …

Objective This paper presents the final analysis of once‐daily darunavir/ritonavir ( DRV /r) vs.
lopinavir/ritonavir ( LPV /r) in treatment‐naïve HIV ‐1‐infected adults. Methods ARTEMIS ( …

Male bottlenose dolphins (Tursiops sp.) in Shark Bay have one of the most complex male
societies outside humans. Two broad mating strategies have been identified in males. In the …

Objective: ODIN (Once-daily Darunavir In treatment-experieNced patients) was a phase III,
48-week, open-label study comparing once-daily vs. twice-daily darunavir/ritonavir (DRV/r) in …

Background Cobicistat is an alternative pharmacoenhancer to ritonavir. In healthy
volunteers, darunavir exposure was comparable when darunavir 800 mg once daily was co-…

Synaptic dysfunction and disconnectivity are core deficits in Alzheimer’s disease (AD),
preceding clear changes in histopathology and cognitive functioning. Here, the early and late …

This study compared the bioavailability of two candidate fixed‐dose combinations (FDCs:
G003 and G004) of darunavir/cobicistat 800/150 mg with that of darunavir 800 mg and ritonavir …

Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related
to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis …