User profiles for Sven Hammerschmidt

Sven Hammerschmidt

Professor of Infection Biology, General and Molecular Genetics
Verified email at uni-greifswald.de
Cited by 14557

α‐Enolase of Streptococcus pneumoniae is a plasmin(ogen)‐binding protein displayed on the bacterial cell surface

…, GS Chhatwal, S Hammerschmidt - Molecular …, 2001 - Wiley Online Library
Binding of human plasminogen to Streptococcus pneumoniae and its subsequent activation
promotes penetration of bacteria through reconstituted basement membranes. In this study, …

Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells

S Hammerschmidt, S Wolff, A Hocke… - Infection and …, 2005 - Am Soc Microbiol
The capsular polysaccharide of Streptococcus pneumoniae represents an important
virulence factor and protects against phagocytosis. In this study the amount of capsular …

[HTML][HTML] Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

…, AC Hocke, S Rosseau, S Hammerschmidt… - Journal of Biological …, 2004 - ASBMB
Streptococcus pneumoniae, the major cause of community-acquired pneumonia and bacterial
meningitis, has been shown to transiently invade epithelial and endothelial cells. Innate …

SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component

S Hammerschmidt, SR Talay… - Molecular …, 1997 - Wiley Online Library
The interaction of pathogenic bacteria with host serum and matrix proteins is a common
strategy to enhance their virulence. Streptococcus pneumoniae colonizes the human upper …

[PDF][PDF] Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo

…, R Sedlmeier, P Burfeind, S Cichon, S Hammerschmidt… - Immunity, 2011 - cell.com
Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine
mechanism by which mast cell-released heparin increases vascular permeability in vivo. …

Versatility of pneumococcal surface proteins

S Bergmann, S Hammerschmidt - Microbiology, 2006 - microbiologyresearch.org
Surface-exposed proteins are key players during the infectious process of pathogenic
bacteria. The cell surface of the Gram-positive human pathogen Streptococcus pneumoniae is …

Capsule phase variation in Neisseria meningitidis serogroup B by slipped‐strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial …

S Hammerschmidt, A Müller, H Sillmann… - Molecular …, 1996 - Wiley Online Library
A mechanism of capsular polysaccharide phase variation in Neisseria meningitidis is
described. Meningococcal cells of an encapsulated serogroup B strain were used in invasion …

The pavA gene of Streptococcus pneumoniae encodes a fibronectin‐binding protein that is essential for virulence

…, KW Millsap, M Rohde, S Hammerschmidt… - Molecular …, 2001 - Wiley Online Library
Streptococcus pneumoniae colonizes the nasopharynx in up to 40% of healthy subjects,
and is a leading cause of middle ear infections (otitis media), meningitis and pneumonia. …

Glyceraldehyde-3-Phosphate Dehydrogenase of Streptococcus pneumoniae Is a Surface-Displayed Plasminogen-Binding Protein

…, M Rohde, S Hammerschmidt - Infection and immunity, 2004 - Am Soc Microbiol
The recruitment of plasminogen endows the bacterial cell surface of Streptococcus pneumoniae
with proteolytic activity. In this study we demonstrate specific plasmin- and plasminogen-…

Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia

…, T Ittermann, S Maier, S Hammerschmidt… - Blood, The Journal …, 2011 - ashpublications.org
A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is
induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and the …