Clinical significance of small airway obstruction markers in patients with asthma
S Gonem, S Natarajan, D Desai… - Clinical & …, 2014 - Wiley Online Library
Background The role of small airway obstruction in the clinical expression of asthma is
incompletely understood. Objective We tested the hypotheses that markers of small airway …
incompletely understood. Objective We tested the hypotheses that markers of small airway …
[HTML][HTML] The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma
S Natarajan, RC Free, P Bradding, L McGarvey… - Respiratory …, 2017 - Springer
Background Severe asthma is characterised by a variety of symptoms, which include chronic
cough, however the mechanisms responsible for cough reflex hypersensitivity in asthma …
cough, however the mechanisms responsible for cough reflex hypersensitivity in asthma …
[HTML][HTML] A systematic review of the diagnostic accuracy of volatile organic compounds in airway diseases and their relation to markers of type-2 inflammation
W Ibrahim, S Natarajan, M Wilde, R Cordell… - ERJ Open …, 2021 - Eur Respiratory Soc
Background Asthma and COPD continue to cause considerable diagnostic and treatment
stratification challenges. Volatile organic compounds (VOCs) have been proposed as feasible …
stratification challenges. Volatile organic compounds (VOCs) have been proposed as feasible …
Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK
Objectives To assess the applicability of risk factors for severe COVID-19 defined in the
general population for patients on haemodialysis. Setting A retrospective cross-sectional study …
general population for patients on haemodialysis. Setting A retrospective cross-sectional study …
[HTML][HTML] Characterising the role of small airways in severe asthma using low frequency forced oscillations: a combined computational and clinical approach
Background Within asthma, the small airways (≤2 mm in diameter) play an important role in
pathophysiology. Using a combined clinical-computational approach, we sought to more …
pathophysiology. Using a combined clinical-computational approach, we sought to more …
S45 Specific ventilation inequality and dead space components of lung clearance index in patients with asthma and cystic fibrosis
S Gonem, S Natarajan, A Singapuri, C Brightling… - Thorax, 2013 - thorax.bmj.com
Background Lung clearance index (LCI) is a widely reported marker of gas mixing
inefficiency within the airways that is derived using the multiple breath inert gas washout (MBW) …
inefficiency within the airways that is derived using the multiple breath inert gas washout (MBW) …
Two-compartment model of gas mixing in patients with asthma and cystic fibrosis
S Gonem, S Natarajan, S Corkill, A Singapuri, D Desai… - 2013 - Eur Respiratory Soc
Background Lung clearance index (LCI) is a widely reported marker of ventilation heterogeneity
(VH) derived from multiple breath inert gas washout. Aims and hypotheses We aimed to …
(VH) derived from multiple breath inert gas washout. Aims and hypotheses We aimed to …
Clinical significance of ventilation heterogeneity in adult patients with asthma
S Gonem, S Natarajan, D Desai, C Newby, S Corkill… - 2013 - Eur Respiratory Soc
Background Ventilation heterogeneity (VH), measured using multiple breath inert gas washout
(MBW), is thought to be a sensitive marker of small airway obstruction. We hypothesised …
(MBW), is thought to be a sensitive marker of small airway obstruction. We hypothesised …
Infection associated phenotype of asthma: Results of a difficult asthma clinic service improvement project
Background: Patients with asthma experiencing recurrent infective exacerbations are started
on prophylactic antibiotics but this phenotype of asthma is not well defined. We sought to; a) …
on prophylactic antibiotics but this phenotype of asthma is not well defined. We sought to; a) …
Evaluation of novel parameters of ventilation heterogeneity in asthma
Background: Lung clearance index (LCI) is the most frequently reported marker of ventilation
heterogeneity (VH) measured non-invasively through multiple breath gas washout (MBW). …
heterogeneity (VH) measured non-invasively through multiple breath gas washout (MBW). …