Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione
levels to degenerative processes and tumor suppression. By performing a genome-wide …

Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that
promote oxidation within the lipid compartment. Calcium (Ca 2+ ) is a signaling molecule in …

Aims Heart failure with preserved ejection fraction ( HFpEF ) is increasingly common, but the
underlying cellular mechanisms are not well understood. We investigated cardiomyocyte …

In recent years, dengue has been rapidly spreading and growing in the tropics and
subtropics. Located in southern China, Hong Kong’s subtropical monsoon climate may favour …

Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-inducible
factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A mRNA …

Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-II)
in human pancreatic tissue sections and to analyse its induction in human islets. Methods …

Bone healing involves a variety of different cell types and biological processes. Although
certain key molecules have been identified, the molecular interactions of the healing progress …

Background As CRISPR/Cas9 mediated screens with pooled guide libraries in somatic cells
become increasingly established, an unmet need for rapid and accurate companion …

Nonsense‐mediated decay (NMD) proteins are responsible for the surveillance and degradation
of aberrant RNAs. Suppressor with morphogenetic effect on genitalia 7 (SMG7) is an …

Species have evolved unique mechanisms to combat the effects of oxidative stress inside
cells. A particularly devastating consequence of an unhindered oxidation of membrane lipids …