Rationale: The ADEPT study aimed to correlate clinical features and accessible biomarkers
with molecular characteristics by profiling asthmatics across severities and healthy …

… Author links open overlay panel Steven G. Kelsen MD a , Ioana O. Agache MD, PhD b ,
Weily Soong MD c , Elliot Israel MD d , Geoffrey L. Chupp MD e , Dorothy S. …

Cigarette smoking, which exposes the lung to high concentrations of reactive oxidant species
(ROS) is the major risk factor for chronic obstructive pulmonary disease (COPD). Recent …

Rationale: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related,
inflammatory lung disease in which tumor necrosis factor-α is overexpressed and has …

To test the hypothesis that aging is associated with a reduction in the diaphragm's force-generating
capacity, we compared the maximum transdiaphragmatic pressure (Pdimax) …

… (From Zhang Y, Kelsen SG: Effects of aging on diaphragm contractile function in golden …
Zhang Y, Kelsen SG: Effects of aging on diaphragm contractile function in golden hamsters. …

Activation of the chemokine receptor CXCR3 by its cognate ligands induces several differentiated
cellular responses important to the growth and migration of a variety of hematopoietic …

Objectives: To determine whether Nrf2-regulated proteasome function affects ER stress-mediated
apoptosis in COPD. Methods: We assessed the expression of Nrf2, Nrf2-dependent …

Background Quilizumab, a humanized IgG1 monoclonal antibody, targets the M1-prime
segment of membrane-expressed IgE, leading to depletion of IgE-switched and memory B cells. …

Human airway epithelial cells (HAEC) constitutively express the CXC chemokine receptor
CXCR3, which regulates epithelial cell movement. In diseases such as chronic obstructive …