Genetic contributions to the cause of type 1 diabetes have been studied for more than 30
years, but only recently, with modern genetic tools, has the importance of seemingly minor …

Research on mapping diabetes-susceptibility genes is dependent on several factors,
including the existence of a single major gene for susceptibility, genetic homogeneity, and the …

The discovery of the association between HLA in the major histocompatibility complex (MHC)
on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested that …

Motivation: Genome-wide association studies (GWASs) have been widely used to map loci
contributing to variation in complex traits and risk of diseases in humans. Accurate …

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of
multiple genetic and environmental risk factors. We report the findings of a genome-wide …

Structural variants (SVs) rearrange large segments of DNA 1 and can have profound
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate
nutrient intake plus additional environmental insults. To investigate the role of the gut …

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance 1 , 2 . When MI occurs early in life, genetic inheritance is a major …