IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
…, L Gogsadze, E Bakhsoliani, S Traub… - American journal of …, 2014 - atsjournals.org
Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived …
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived …
Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing
MM Martino, F Tortelli, M Mochizuki, S Traub… - Science translational …, 2011 - science.org
Although growth factors naturally exert their morphogenetic influences within the context of
the extracellular matrix microenvironment, the interactions among growth factors, their …
the extracellular matrix microenvironment, the interactions among growth factors, their …
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma
…, I Dragoni, J Silvester, K Dyer, S Traub… - Science Translational …, 2020 - science.org
The reprogramming of a patient’s immune system through genetic modification of the T cell
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …
[HTML][HTML] TLR8 deficiency leads to autoimmunity in mice
O Demaria, PP Pagni, S Traub… - The Journal of …, 2010 - Am Soc Clin Investig
TLRs play an essential role in the induction of immune responses by detecting conserved
molecular products of microorganisms. However, the function of TLR8 is largely unknown. In …
molecular products of microorganisms. However, the function of TLR8 is largely unknown. In …
Invited review: MDP and other muropeptides—direct and synergistic effects on the immune system
S Traub, S von Aulock, T Hartung… - Journal of endotoxin …, 2006 - journals.sagepub.com
Muropeptides are breakdown products of peptidoglycan (PGN) of Gram-negative and Gram-positive
bacteria. They are released during bacterial growth and division, as part of the host …
bacteria. They are released during bacterial growth and division, as part of the host …
Cutting edge: overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection
N Zucchini, G Bessou, S Traub, SH Robbins… - The Journal of …, 2008 - journals.aai.org
As initially demonstrated with murine cytomegalovirus (MCMV), plasmacytoid dendritic cells
(pDCs) are the major source of IFN-α/β in response to a variety of viruses in vivo. However, …
(pDCs) are the major source of IFN-α/β in response to a variety of viruses in vivo. However, …
[PDF][PDF] The use of digital pathology and image analysis in clinical trials
…, JM Beecham, S Traub… - The Journal of …, 2019 - Wiley Online Library
Digital pathology and image analysis potentially provide greater accuracy, reproducibility and
standardisation of pathology‐based trial entry criteria and endpoints, alongside extracting …
standardisation of pathology‐based trial entry criteria and endpoints, alongside extracting …
[HTML][HTML] An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation
S Traub, A Nikonova, A Carruthers, R Dunmore… - PLoS …, 2013 - journals.plos.org
Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of
asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently …
asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently …
[HTML][HTML] M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus …
A Nikonova, M Khaitov, DJ Jackson, S Traub… - …, 2020 - thelancet.com
Background Macrophages (Mф) can be M1/M2 polarized by Th1/2 signals, respectively. M2-like
Mф are thought to be important in asthma pathogenesis, and M1-like in anti-infective …
Mф are thought to be important in asthma pathogenesis, and M1-like in anti-infective …
First-in-human study of AT13148, a dual ROCK-AKT inhibitor in patients with solid tumors
Purpose: AT13148 is an oral AGC kinase inhibitor, which potently inhibits ROCK and AKT
kinases. In preclinical models, AT13148 has been shown to have antimetastatic and …
kinases. In preclinical models, AT13148 has been shown to have antimetastatic and …