Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

…, B Eiz-Vesper, R Blasczyk, S Immenschuh - Biochemical …, 2010 - Elsevier
Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

Gene regulation of heme oxygenase-1 as a therapeutic target

S Immenschuh, G Ramadori - Biochemical pharmacology, 2000 - Elsevier
Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme
degradation. HO regulates the cellular content of the pro-oxidant heme and produces catabolites …

Peroxiredoxins, oxidative stress, and cell proliferation

S Immenschuh, E Baumgart-Vogt - Antioxidants & redox signaling, 2005 - liebertpub.com
Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thioredoxin-dependent
peroxidases that have been identified in a large variety of organisms. The major functions of Prxs …

[HTML][HTML] The macrophage heme-heme oxygenase-1 system and its role in inflammation

V Vijayan, FA Wagener, S Immenschuh - Biochemical pharmacology, 2018 - Elsevier
Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO, plays a
critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells

…, S Schürger, N Wijayanti, S Immenschuh… - Free Radical Biology …, 2004 - Elsevier
Cholesterol-independent, pleiotropic actions of hydroxymethylglutaryl coenzyme A (HMG-CoA)
reductase inhibitors (statins) exert anti-inflammatory and antioxidant action by as yet …

[HTML][HTML] Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes

T Kietzmann, A Samoylenko, S Immenschuh - Journal of Biological …, 2003 - ASBMB
Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli
including sodium arsenite. Since mitogen-activated protein kinases (MAPKs) are involved in …

[HTML][HTML] Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide-A divergent role for glycolysis

…, F Gueler, R Motterlini, R Foresti, S Immenschuh - Redox biology, 2019 - Elsevier
Macrophages adopt different phenotypes in response to microenvironmental changes, which
can be principally classified into inflammatory and anti-inflammatory states. Inflammatory …

[HTML][HTML] Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections

FA Wagener, P Pickkers, SJ Peterson, S Immenschuh… - Antioxidants, 2020 - mdpi.com
SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19
patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and …

Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2

…, S Santoso, T Kietzmann, S Immenschuh - The Journal of …, 2009 - journals.aai.org
Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of heme
degradation. The HO products carbon monoxide and bilirubin not only provide antioxidant …

[HTML][HTML] Heme as a target for therapeutic interventions

S Immenschuh, V Vijayan, S Janciauskiene… - Frontiers in …, 2017 - frontiersin.org
Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …