The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits
natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface …

The glycolipid α-galactosylceramide binds with high affinity to CD1d and stimulates natural
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α-…

Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other
inflammatory processes, and these cells can be activated through their T cell antigen …

The human genome encodes five nonpolymorphic major histocompatibility complex class I–like
glycoproteins, CD1a to CD1e, that present lipid antigens for specific recognition by T …

Objective: To analyse the performance of a new M tuberculosis-specific interferon γ (IFNγ)
assay in patients with chronic inflammatory diseases who receive immunosuppressive drugs, …

The use of protein-based anti-TNF-α therapies such as antibodies and soluble TNF-α
receptors is commonly associated with the induction of autoantibodies, whereas anti-TNF-induced …

OBJECTIVE: Evidence for effective management of shoulder impingement is limited. The
present study aimed to quantify the clinical, neurophysiological, and biomechanical effects of a …

Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …

Background The number of type 2 helper CD4+ T cells is increased in the airways of
persons with asthma. Whether the majority of these cells are class II major-histocompatibility-…

Background Doxycycline is often used for treating COVID-19 respiratory symptoms in the
community despite an absence of evidence from clinical trials to support its use. We aimed to …