[HTML][HTML] Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals

A Thess, S Grund, BL Mui, MJ Hope, P Baumhof… - Molecular Therapy, 2015 - cell.com
Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and
safe means for protein therapies. While recent findings highlight the enormous therapeutic …

[HTML][HTML] Strategien zur Sedimentbewertung–ein Überblick

…, T Kosmehl, S Keiter, S Grund… - Environmental …, 2009 - enveurope.springeropen.com
Hintergrund Sedimente sind als wichtiger Faktor bei der Beurteilung der Gewässerqualität
in den letzten Jahren stärker in die wissenschaftliche und öffentliche Diskussion geraten. …

The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation

…, M Groß, P Mestdagh, J Schott, SE Grund… - Oncogene, 2018 - nature.com
Breast cancer is a leading cause of cancer-related death in women. Small open reading
frame (sORF)-encoded proteins or microproteins constitute a new class of molecules often …

Comparison of in vitro and in situ genotoxicity in the Danube River by means of the comet assay and the micronucleus test

M Boettcher, S Grund, S Keiter, T Kosmehl… - … /Genetic Toxicology and …, 2010 - Elsevier
Genotoxicity can be correlated with adverse reproductive effects or may even result in elevated
extinction risk for particular species of an ecosystem. It may thus be a valuable tool for …

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

SE Grund, T Fischer, GG Cabal, O Antúnez… - The Journal of cell …, 2008 - rupress.org
Inner nuclear membrane proteins containing a LEM (LAP2, emerin, and MAN1) domain
participate in different processes, including chromatin organization, gene expression, and …

Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river

S Keiter, S Grund, B Van Bavel, J Hagberg… - Analytical and …, 2008 - Springer
This study is a consequence of a distinct fish decline in the Danube river since the beginning
of the 1990s. In contrast to the decline of fish population, former studies have repeatedly …

The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

…, J Newsted, J Laskey, A Buckalew, S Grund… - … Science and Pollution …, 2011 - Springer
Background, goals, and scope In response to increasing concerns regarding the potential of
chemicals to interact with the endocrine system of humans and wildlife, various national and …

The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis

S Grund, E Higley, R Schönenberger, MJF Suter… - … Science and Pollution …, 2011 - Springer
Introduction The present study was part of a comprehensive weight-of-evidence approach
with the goal of identifying potential causes for the declines in fish populations, which have …

Alternative splicing affects the subcellular localization of Drosha

S Link, SE Grund, S Diederichs - Nucleic acids research, 2016 - academic.oup.com
The RNase III enzyme Drosha is a key factor in microRNA (miRNA) biogenesis and as such
indispensable for cellular homeostasis and developmental processes. Together with its co-…

The OECD Validation Program of the H295R Steroidogenesis Assay for the Identification of In Vitro Inhibitors and Inducers of Testosterone and Estradiol Production …

…, R Wu, P Lam, J Laskey, A Buckalew, S Grund… - … Science and Pollution …, 2007 - Springer
Background Goals and Scope. In response to concerns that have been raised about chemical
substances that may alter the function of endocrine systems and result in adverse effects …