MATERIALS AND METHODS+ H, O,). The enzyme has proven to be a useful probe for
studying the participation of the radical in reac---tions involving oxygen such as autoxidations. …

Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons.
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …

A superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1), distinct from
previously known superoxide dismutases, has been isolated from human lung tissue. It is …

The contents of extracellular superoxide dismutase, CuZn superoxide dismutase and Mn
superoxide dismutase were determined in tissues from nine mammalian species. The pattern …

Exogenous superoxide dismutase, catalase and scavengers of the hydroxyl radical protect
pancreatic-islet cells against the toxic actions of alloxan in vitro [Grankvist et al. (1979) …

Serum from healthy volunteers contained very little CuZn Superoxide dismutase. Larger
amounts were found in serum from patients with impaired renal function, and there was a good …

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide
dismutase, catalase, and glutathione peroxidase form the primary enzymic defense against toxic …

Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that
previously has been demonstrated to be the major superoxide dismutase of human extracellular …

Analysis of the entire set of low molecular weight compounds (LMC), the metabolome, could
provide deeper insights into mechanisms of disease and novel markers for diagnosis. In the …

One cause of amyotrophic lateral sclerosis (ALS) is mutation in ubiquitously expressed
copper/zinc superoxide dismutase (SOD1), but the mechanism of toxicity to motor neurons is …