User profiles for Simon C. Robson
Simon C. RobsonCharlotte F. and Irving W. Rabb Professor of Medicine at Harvard Medical School Verified email at bidmc.harvard.edu Cited by 44362 |
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
…, M Oukka, VK Kuchroo, TB Strom, SC Robson - The Journal of …, 2007 - rupress.org
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface
markers and an inability to define mechanisms of suppression. We show that the expression of …
markers and an inability to define mechanisms of suppression. We show that the expression of …
[HTML][HTML] The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective
nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme …
nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme …
[HTML][HTML] Identification and characterization of CD39/vascular ATP diphosphohydrolase
…, J Anrather, AR Beaudoin, FH Bach, SC Robson - Journal of Biological …, 1996 - ASBMB
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that
hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available …
hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available …
Negative feedback control of neuronal activity by microglia
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying
neurons, pruning non-functional synapses, and producing ligands that support neuronal …
neurons, pruning non-functional synapses, and producing ligands that support neuronal …
Heart transplantation in baboons using α1, 3-galactosyltransferase gene-knockout pigs as donors: initial experience
…, C Patience, M Awwad, JA Fishman, SC Robson… - Nature medicine, 2005 - nature.com
Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted
heterotopically into baboons using an anti-CD154 monoclonal antibody–based regimen. The …
heterotopically into baboons using an anti-CD154 monoclonal antibody–based regimen. The …
The ectonucleotidases CD 39 and CD 73: novel checkpoint inhibitor targets
Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …
Purinergic signaling during inflammation
…, MV Sitkovsky, SC Robson - New England Journal of …, 2012 - Mass Medical Soc
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …
important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged …
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium: Role of Ectonucleotidases and Adenosine A2B …
…, KA Jacobson, K Enjyoji, SC Robson… - The Journal of …, 2003 - rupress.org
Limited oxygen delivery to tissues (hypoxia) is common in a variety of disease states. A number
of parallels exist between hypoxia and acute inflammation, including the observation that …
of parallels exist between hypoxia and acute inflammation, including the observation that …
Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
Mouse-to-rat cardiac transplants survive long term after transient complement depletion by
cobra venom factor and T cell immunosuppression by cyclosporin A. Expression of heme …
cobra venom factor and T cell immunosuppression by cyclosporin A. Expression of heme …